Chronic urotensin-II infusion induces diastolic dysfunction and enhances collagen production in rats

• Main Authors: Lavinia Tran, Andrew R. Kompa, Will Kemp, Arintaya Phrommintikul, Bing H. Wang, Henry Krum
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=74949086624&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50600
• Institution: Chiang Mai University

The vasoactive peptide urotensin-II (U-II) is likely to play a key causal role in cardiac remodeling that ultimately leads to heart failure. Its contribution, specifically to the development of diastolic dysfunction and the downstream intracellular signaling, however, remains unresolved. This study...