Cilostazol attenuates ventricular arrhythmia induction and improves defibrillation efficacy in swine

• Main Authors: Natnicha Kanlop, Krekwit Shinlapawittayatorn, Rattapong Sungnoon, Punate Weerateerangkul, Siriporn Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952026026&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50615
• Institution: Chiang Mai University

Previous reports demonstrated that cilostazol, a phosphodiesterase 3 inhibitor, affected cellular electrophysiology and reduced episodes of ventricular fibrillation (VF) in patients with Brugada syndrome. However, its effects on VF induction and defibrillation efficacy have never been investigated....