Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure

Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256...

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Main Authors: Kowit Nambunmee, Ryumond Honda, Muneko Nishijo, Witaya Swaddiwudhipong, Hideaki Nakagawa, Werawan Ruangyuttikarn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-509032018-09-04T04:52:54Z Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure Kowit Nambunmee Ryumond Honda Muneko Nishijo Witaya Swaddiwudhipong Hideaki Nakagawa Werawan Ruangyuttikarn Environmental Science Pharmacology, Toxicology and Pharmaceutics Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256 women aged≥50) were selected on the basis of previous records of elevated urinary cadmium and tested for urinary and blood cadmium, bone formation and resorption markers, and the renal tubular dysfunction markers. Both genders had high levels of blood and urinary cadmium and high urinary levels of the markers for renal dysfunction and bone resorption in a doseresponse relationship to urinary cadmium. The excretion of bone resorption markers was positively correlated to the ratio of excreted calcium and urinary cadmium. The results of a multivariate regression analysis indicated that bone resorption was accelerated by impaired calcium reabsorption in renal tubules. © 2010 Informa UK Ltd. 2018-09-04T04:47:14Z 2018-09-04T04:47:14Z 2010-01-01 Journal 15376524 15376516 2-s2.0-77149169461 10.3109/15376510903452941 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77149169461&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Environmental Science
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Environmental Science
Pharmacology, Toxicology and Pharmaceutics
Kowit Nambunmee
Ryumond Honda
Muneko Nishijo
Witaya Swaddiwudhipong
Hideaki Nakagawa
Werawan Ruangyuttikarn
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
description Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256 women aged≥50) were selected on the basis of previous records of elevated urinary cadmium and tested for urinary and blood cadmium, bone formation and resorption markers, and the renal tubular dysfunction markers. Both genders had high levels of blood and urinary cadmium and high urinary levels of the markers for renal dysfunction and bone resorption in a doseresponse relationship to urinary cadmium. The excretion of bone resorption markers was positively correlated to the ratio of excreted calcium and urinary cadmium. The results of a multivariate regression analysis indicated that bone resorption was accelerated by impaired calcium reabsorption in renal tubules. © 2010 Informa UK Ltd.
format Journal
author Kowit Nambunmee
Ryumond Honda
Muneko Nishijo
Witaya Swaddiwudhipong
Hideaki Nakagawa
Werawan Ruangyuttikarn
author_facet Kowit Nambunmee
Ryumond Honda
Muneko Nishijo
Witaya Swaddiwudhipong
Hideaki Nakagawa
Werawan Ruangyuttikarn
author_sort Kowit Nambunmee
title Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
title_short Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
title_full Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
title_fullStr Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
title_full_unstemmed Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
title_sort bone resorption acceleration and calcium reabsorption impairment in a thai population with high cadmium exposure
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77149169461&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903
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