Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure
Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77149169461&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-50903 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-509032018-09-04T04:52:54Z Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure Kowit Nambunmee Ryumond Honda Muneko Nishijo Witaya Swaddiwudhipong Hideaki Nakagawa Werawan Ruangyuttikarn Environmental Science Pharmacology, Toxicology and Pharmaceutics Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256 women aged≥50) were selected on the basis of previous records of elevated urinary cadmium and tested for urinary and blood cadmium, bone formation and resorption markers, and the renal tubular dysfunction markers. Both genders had high levels of blood and urinary cadmium and high urinary levels of the markers for renal dysfunction and bone resorption in a doseresponse relationship to urinary cadmium. The excretion of bone resorption markers was positively correlated to the ratio of excreted calcium and urinary cadmium. The results of a multivariate regression analysis indicated that bone resorption was accelerated by impaired calcium reabsorption in renal tubules. © 2010 Informa UK Ltd. 2018-09-04T04:47:14Z 2018-09-04T04:47:14Z 2010-01-01 Journal 15376524 15376516 2-s2.0-77149169461 10.3109/15376510903452941 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77149169461&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Environmental Science Pharmacology, Toxicology and Pharmaceutics |
spellingShingle |
Environmental Science Pharmacology, Toxicology and Pharmaceutics Kowit Nambunmee Ryumond Honda Muneko Nishijo Witaya Swaddiwudhipong Hideaki Nakagawa Werawan Ruangyuttikarn Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
description |
Some residents of the Mae Sot district in Thailand have suffered long-term exposure to elevated dietary levels of cadmium. To test the hypothesis that chronic dietary cadmium exposure can cause imbalance in calcium dynamics and accelerate bone resorption, a group of these residents (156 men and 256 women aged≥50) were selected on the basis of previous records of elevated urinary cadmium and tested for urinary and blood cadmium, bone formation and resorption markers, and the renal tubular dysfunction markers. Both genders had high levels of blood and urinary cadmium and high urinary levels of the markers for renal dysfunction and bone resorption in a doseresponse relationship to urinary cadmium. The excretion of bone resorption markers was positively correlated to the ratio of excreted calcium and urinary cadmium. The results of a multivariate regression analysis indicated that bone resorption was accelerated by impaired calcium reabsorption in renal tubules. © 2010 Informa UK Ltd. |
format |
Journal |
author |
Kowit Nambunmee Ryumond Honda Muneko Nishijo Witaya Swaddiwudhipong Hideaki Nakagawa Werawan Ruangyuttikarn |
author_facet |
Kowit Nambunmee Ryumond Honda Muneko Nishijo Witaya Swaddiwudhipong Hideaki Nakagawa Werawan Ruangyuttikarn |
author_sort |
Kowit Nambunmee |
title |
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
title_short |
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
title_full |
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
title_fullStr |
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
title_full_unstemmed |
Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure |
title_sort |
bone resorption acceleration and calcium reabsorption impairment in a thai population with high cadmium exposure |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77149169461&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50903 |
_version_ |
1681423673418842112 |