Pulvinar projections to the striatum and amygdala in the tree shrew

Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as "blindsight" Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from...

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Main Authors: Jonathan D. Day-Brown, Haiyang Wei, Ranida D. Chomsung, Heywood M. Petry, Martha E. Bickford
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51026
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-510262018-09-04T04:52:15Z Pulvinar projections to the striatum and amygdala in the tree shrew Jonathan D. Day-Brown Haiyang Wei Ranida D. Chomsung Heywood M. Petry Martha E. Bickford Medicine Neuroscience Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as "blindsight" Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus. To define potential pathways that underlie behavioral responses to unperceived visual stimuli, we examined the projections from the pulvinar nucleus to the striatum and amygdala in the tree shrew (Tupaia belangeri), a species considered to be a prototypical primate. The tree shrew brain has a large pulvinar nucleus that contains two SC-recipient subdivisions; the dorsal (Pd) and central (Pc) pulvinar both receive topographic ("specific") projections from SC, and Pd receives an additional non-topographic ("diffuse") projection from SC (Chomsung et al., 2008). Anterograde and retrograde tract tracing revealed that both Pd and Pc project to the caudate and putamen, and Pd, but not Pc, additionally projects to the lateral amygdala. Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix. Confocal microscopy revealed that tracer-labeled pulvino-striatal terminals preferentially innervate the matrix. Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images. © 2010 Day-brown, Wei, Chomsung, Petry and Bickford. 2018-09-04T04:50:20Z 2018-09-04T04:50:20Z 2010-11-15 Journal 16625129 2-s2.0-84862999602 10.3389/fnana.2010.00143 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862999602&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51026
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Jonathan D. Day-Brown
Haiyang Wei
Ranida D. Chomsung
Heywood M. Petry
Martha E. Bickford
Pulvinar projections to the striatum and amygdala in the tree shrew
description Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as "blindsight" Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus. To define potential pathways that underlie behavioral responses to unperceived visual stimuli, we examined the projections from the pulvinar nucleus to the striatum and amygdala in the tree shrew (Tupaia belangeri), a species considered to be a prototypical primate. The tree shrew brain has a large pulvinar nucleus that contains two SC-recipient subdivisions; the dorsal (Pd) and central (Pc) pulvinar both receive topographic ("specific") projections from SC, and Pd receives an additional non-topographic ("diffuse") projection from SC (Chomsung et al., 2008). Anterograde and retrograde tract tracing revealed that both Pd and Pc project to the caudate and putamen, and Pd, but not Pc, additionally projects to the lateral amygdala. Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix. Confocal microscopy revealed that tracer-labeled pulvino-striatal terminals preferentially innervate the matrix. Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images. © 2010 Day-brown, Wei, Chomsung, Petry and Bickford.
format Journal
author Jonathan D. Day-Brown
Haiyang Wei
Ranida D. Chomsung
Heywood M. Petry
Martha E. Bickford
author_facet Jonathan D. Day-Brown
Haiyang Wei
Ranida D. Chomsung
Heywood M. Petry
Martha E. Bickford
author_sort Jonathan D. Day-Brown
title Pulvinar projections to the striatum and amygdala in the tree shrew
title_short Pulvinar projections to the striatum and amygdala in the tree shrew
title_full Pulvinar projections to the striatum and amygdala in the tree shrew
title_fullStr Pulvinar projections to the striatum and amygdala in the tree shrew
title_full_unstemmed Pulvinar projections to the striatum and amygdala in the tree shrew
title_sort pulvinar projections to the striatum and amygdala in the tree shrew
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862999602&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51026
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