Analysis of real-time PCR cycle threshold of α-thalassemia-1 southeast asian type deletion using fetal cell-free DNA in maternal plasma for noninvasive prenatal diagnosis of bart's hydrops fetalis

• Main Authors: Sakorn Pornprasert, Kanyakan Sukunthamala, Naowarat Kunyanone, Sririchai Sittiprasert, Khanungnit Thungkham, Sumeth Junorse, Khachonsilp Pongsawatkul, Wisut Pattanaporn, Chantip Jitwong, Torpong Sanguansermsri
• 格式: 雜誌
• 出版: 2018
• 主題: Medicine
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78649272558&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51032
• 機構: Chiang Mai University

Background: Noninvasive prenatal diagnosis based on detection of fetal cell-free DNA is hampered when mother and father are both carriers for the same autosomal recessive mutation. Objective: To compare the diagnosis of Bart's hydrops fetalis using conventional Gap-PCR analysis of fetal cells/t...