Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report

The authors report a rare case of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) with congenital neuroblastoma without feature(s) of Beckwith-Wiedemann syndrome. A term newborn with a birth weight of 3,900g developed hypoglycemia one hour after birth and required up to 20 mg/kg/min of in...

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Main Authors: Prapai Dejkhamron, Kevalee Unachak, Pattra Thanarattanakorn, Pimlak D. Charoenkwan, Watcharee Tantiprabha, Somporn Chotinaruemol, Benjaporn Chaiwun MD
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51061
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-510612018-09-04T04:50:58Z Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report Prapai Dejkhamron Kevalee Unachak Pattra Thanarattanakorn Pimlak D. Charoenkwan Watcharee Tantiprabha Somporn Chotinaruemol Benjaporn Chaiwun MD Medicine The authors report a rare case of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) with congenital neuroblastoma without feature(s) of Beckwith-Wiedemann syndrome. A term newborn with a birth weight of 3,900g developed hypoglycemia one hour after birth and required up to 20 mg/kg/min of intravenous glucose infusion to maintain euglycemia. Investigations during the critical period revealed an inappropriately high insulin level. An abdominal CT scan revealed a normal pancreas, right suprarenal mass, and liver nodules. A condition of stage 4S neuroblastoma was suspected and supported by an increased ratio of urine vanillylmandelic acid to creatinine. The bone marrow smear was normal. She underwent near total pancreatectomy at the age of 2 months. The suprarenal mass and liver nodules were not found during the operation or during repeated abdominal CT scans at 3 month of age. Spontaneous regression of neuroblastoma was suspected. The pathology of the pancreas was compatible with PHHI. 2018-09-04T04:50:58Z 2018-09-04T04:50:58Z 2010-06-01 Journal 01252208 01252208 2-s2.0-77954481356 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954481356&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51061
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Prapai Dejkhamron
Kevalee Unachak
Pattra Thanarattanakorn
Pimlak D. Charoenkwan
Watcharee Tantiprabha
Somporn Chotinaruemol
Benjaporn Chaiwun MD
Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
description The authors report a rare case of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) with congenital neuroblastoma without feature(s) of Beckwith-Wiedemann syndrome. A term newborn with a birth weight of 3,900g developed hypoglycemia one hour after birth and required up to 20 mg/kg/min of intravenous glucose infusion to maintain euglycemia. Investigations during the critical period revealed an inappropriately high insulin level. An abdominal CT scan revealed a normal pancreas, right suprarenal mass, and liver nodules. A condition of stage 4S neuroblastoma was suspected and supported by an increased ratio of urine vanillylmandelic acid to creatinine. The bone marrow smear was normal. She underwent near total pancreatectomy at the age of 2 months. The suprarenal mass and liver nodules were not found during the operation or during repeated abdominal CT scans at 3 month of age. Spontaneous regression of neuroblastoma was suspected. The pathology of the pancreas was compatible with PHHI.
format Journal
author Prapai Dejkhamron
Kevalee Unachak
Pattra Thanarattanakorn
Pimlak D. Charoenkwan
Watcharee Tantiprabha
Somporn Chotinaruemol
Benjaporn Chaiwun MD
author_facet Prapai Dejkhamron
Kevalee Unachak
Pattra Thanarattanakorn
Pimlak D. Charoenkwan
Watcharee Tantiprabha
Somporn Chotinaruemol
Benjaporn Chaiwun MD
author_sort Prapai Dejkhamron
title Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
title_short Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
title_full Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
title_fullStr Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
title_full_unstemmed Case report: Persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: A case report
title_sort case report: persistent hyperinsulinemic hypoglycemia of infancy associated with congenital neuroblastoma: a case report
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954481356&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51061
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