Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review

The presence of osteoclast-like giant cells (OGC) has been reported as a rare and distinct feature in uterine leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an additional example in a 35-year-old woman who presented with a pelvic mass...

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Main Authors: Kornkanok Sukpan, Surapan Khunamornpong, Prapaporn Suprasert, Sumalee Siriaunkgul
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51085
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spelling th-cmuir.6653943832-510852018-09-04T04:51:24Z Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review Kornkanok Sukpan Surapan Khunamornpong Prapaporn Suprasert Sumalee Siriaunkgul Medicine The presence of osteoclast-like giant cells (OGC) has been reported as a rare and distinct feature in uterine leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an additional example in a 35-year-old woman who presented with a pelvic mass. Pulmonary metastasis was detected by the preoperative CT scan. The hysterectomy specimen revealed a 11.5 cm intramural mass with hemorrhagic and necrotic center. The histologic examination revealed pleomorphic sarcoma with OGC. The neoplastic cells were immunoreative for smooth muscle actin and desmin. Minor intermixing component of conventional leiomyosarcoma and leiomyoma were identified at the periphery of the malignant component. The patient died of disease after 16 months of diagnosis. To our knowledge, this is the youngest case of uterine leiomyosarcoma with OGC. Leiomyosarcoma with OGC has an aggressive clinical course. The tumor may occur in young patient and may arise from pre-existing leiomyoma. 2018-09-04T04:51:24Z 2018-09-04T04:51:24Z 2010-04-01 Journal 01252208 01252208 2-s2.0-77951921940 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77951921940&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51085
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Kornkanok Sukpan
Surapan Khunamornpong
Prapaporn Suprasert
Sumalee Siriaunkgul
Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
description The presence of osteoclast-like giant cells (OGC) has been reported as a rare and distinct feature in uterine leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an additional example in a 35-year-old woman who presented with a pelvic mass. Pulmonary metastasis was detected by the preoperative CT scan. The hysterectomy specimen revealed a 11.5 cm intramural mass with hemorrhagic and necrotic center. The histologic examination revealed pleomorphic sarcoma with OGC. The neoplastic cells were immunoreative for smooth muscle actin and desmin. Minor intermixing component of conventional leiomyosarcoma and leiomyoma were identified at the periphery of the malignant component. The patient died of disease after 16 months of diagnosis. To our knowledge, this is the youngest case of uterine leiomyosarcoma with OGC. Leiomyosarcoma with OGC has an aggressive clinical course. The tumor may occur in young patient and may arise from pre-existing leiomyoma.
format Journal
author Kornkanok Sukpan
Surapan Khunamornpong
Prapaporn Suprasert
Sumalee Siriaunkgul
author_facet Kornkanok Sukpan
Surapan Khunamornpong
Prapaporn Suprasert
Sumalee Siriaunkgul
author_sort Kornkanok Sukpan
title Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
title_short Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
title_full Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
title_fullStr Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
title_full_unstemmed Leiomyosarcoma with osteoclast-like giant cells of the uterus: A case report and literature review
title_sort leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77951921940&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51085
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