Sex difference in composition of plaques of patients undergoing carotid endarterectomy

Our study aimed to examine the hypothesis that women have more stable plaques (a lower proportion of lipid component and a higher proportion of fibrous tissue) compared to men. Plaque specimens of 141 consecutive carotid endarterectomy patients (60 females and 81 males) were studied. Medical histori...

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Main Authors: Kittipan Rerkasem, Patrick J. Gallagher, Robert F. Grimble, Philip C. Calder, Clifford P. Shearman
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51089
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-510892018-09-04T04:51:26Z Sex difference in composition of plaques of patients undergoing carotid endarterectomy Kittipan Rerkasem Patrick J. Gallagher Robert F. Grimble Philip C. Calder Clifford P. Shearman Medicine Our study aimed to examine the hypothesis that women have more stable plaques (a lower proportion of lipid component and a higher proportion of fibrous tissue) compared to men. Plaque specimens of 141 consecutive carotid endarterectomy patients (60 females and 81 males) were studied. Medical histories were recorded and the plasma concentrations of cholesterol and inflammatory markers were measured. We found that plaques from females had significantly less lipid than those from males (p = .01): the mean percentage of plaque lipid for women and men was 47.8% and 58.2%, respectively. Plaques from females had more fibrous tissue than those from men (p = .02): the mean percentage of fibrous tissue for women and men was 38.8% and 29.8%, respectively. This study concluded that the histology of carotid artery plaques from women appears to be more stable than that of those from men. © BC Decker Inc. All rights reserved. 2018-09-04T04:51:26Z 2018-09-04T04:51:26Z 2010-04-01 Journal 17085381 2-s2.0-77950809151 10.2310/6670.2010.00008 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950809151&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51089
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Kittipan Rerkasem
Patrick J. Gallagher
Robert F. Grimble
Philip C. Calder
Clifford P. Shearman
Sex difference in composition of plaques of patients undergoing carotid endarterectomy
description Our study aimed to examine the hypothesis that women have more stable plaques (a lower proportion of lipid component and a higher proportion of fibrous tissue) compared to men. Plaque specimens of 141 consecutive carotid endarterectomy patients (60 females and 81 males) were studied. Medical histories were recorded and the plasma concentrations of cholesterol and inflammatory markers were measured. We found that plaques from females had significantly less lipid than those from males (p = .01): the mean percentage of plaque lipid for women and men was 47.8% and 58.2%, respectively. Plaques from females had more fibrous tissue than those from men (p = .02): the mean percentage of fibrous tissue for women and men was 38.8% and 29.8%, respectively. This study concluded that the histology of carotid artery plaques from women appears to be more stable than that of those from men. © BC Decker Inc. All rights reserved.
format Journal
author Kittipan Rerkasem
Patrick J. Gallagher
Robert F. Grimble
Philip C. Calder
Clifford P. Shearman
author_facet Kittipan Rerkasem
Patrick J. Gallagher
Robert F. Grimble
Philip C. Calder
Clifford P. Shearman
author_sort Kittipan Rerkasem
title Sex difference in composition of plaques of patients undergoing carotid endarterectomy
title_short Sex difference in composition of plaques of patients undergoing carotid endarterectomy
title_full Sex difference in composition of plaques of patients undergoing carotid endarterectomy
title_fullStr Sex difference in composition of plaques of patients undergoing carotid endarterectomy
title_full_unstemmed Sex difference in composition of plaques of patients undergoing carotid endarterectomy
title_sort sex difference in composition of plaques of patients undergoing carotid endarterectomy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950809151&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51089
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