Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis
This study was performed to determine the prevalence of anti-agalactosyl IgG antibodies in Thai patients with RA, systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), and determine the sensitivity and specificity of anti-agalactosyl IgG antibodies in the diagnosis of RA in comparison wit...
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th-cmuir.6653943832-511022018-09-04T04:51:38Z Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis Worawit Louthrenoo Nuntana Kasitanon Ramjai Wichainun Suparaporn Wangkaew Waraporn Sukitawut Shoji Kuwata Fujio Takeuchi Medicine This study was performed to determine the prevalence of anti-agalactosyl IgG antibodies in Thai patients with RA, systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), and determine the sensitivity and specificity of anti-agalactosyl IgG antibodies in the diagnosis of RA in comparison with IgM-rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Serum samples were obtained from 100 patients with RA, 50 cases of SLE, 50 cases of SSc, and 100 healthy controls and analyzed for the presence of anti-agalactosyl IgG antibodies, IgM-RF and anti-CCP antibodies. A serum value greater than mean+2 standard deviation of normal value of anti-agalactosyl IgG antibodies and anti-CCP antibodies was considered positive. The prevalence of anti-agalactosyl IgG antibodies in RA, SLE, and SSc patients was 88.0%, 14.0%, and 12.0%, respectively. The serum level of anti-agalactosyl IgG antibodies in patients with RA (227.10±353.64 AU/mL) was significantly higher than those in SLE (11.84±52.04 AU/mL), SSc (18.85±99.60 AU/mL), and healthy controls (2.14±1.97 AU/mL), (p<0.001). There was a good correlation between the log serum level of anti-agalactosyl IgG antibodies and IgM-RF (r=0.92, p<0.001), anti-CCP antibodies and IgM-RF (r=0.49, p<0.001), and anti-agalactosyl IgG antibodies and anti-CCP antibodies (r=0.55, p<0.001). The sensitivity and specificity in the diagnosis of RA was 88.00% and 96.00% for anti-agalactosyl IgG antibodies, 90.00% and 99.00% for anti-CCP antibodies, and 91.00% and 95.00% for IgM-RF, respectively. The serum level of anti-agalactosyl IgG antibodies was significantly higher in RA than in SLE, SSc, and healthy controls. There was a good correlation between serum levels of anti-agalactosyl IgG antibodies, anti-CCP antibodies, and IgM-RF. These three tests had comparable sensitivity and specificity. © 2009 Clinical Rheumatology. 2018-09-04T04:51:38Z 2018-09-04T04:51:38Z 2010-03-01 Journal 07703198 2-s2.0-77950614799 10.1007/s10067-009-1284-y https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950614799&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51102 |
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Medicine Worawit Louthrenoo Nuntana Kasitanon Ramjai Wichainun Suparaporn Wangkaew Waraporn Sukitawut Shoji Kuwata Fujio Takeuchi Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
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This study was performed to determine the prevalence of anti-agalactosyl IgG antibodies in Thai patients with RA, systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), and determine the sensitivity and specificity of anti-agalactosyl IgG antibodies in the diagnosis of RA in comparison with IgM-rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Serum samples were obtained from 100 patients with RA, 50 cases of SLE, 50 cases of SSc, and 100 healthy controls and analyzed for the presence of anti-agalactosyl IgG antibodies, IgM-RF and anti-CCP antibodies. A serum value greater than mean+2 standard deviation of normal value of anti-agalactosyl IgG antibodies and anti-CCP antibodies was considered positive. The prevalence of anti-agalactosyl IgG antibodies in RA, SLE, and SSc patients was 88.0%, 14.0%, and 12.0%, respectively. The serum level of anti-agalactosyl IgG antibodies in patients with RA (227.10±353.64 AU/mL) was significantly higher than those in SLE (11.84±52.04 AU/mL), SSc (18.85±99.60 AU/mL), and healthy controls (2.14±1.97 AU/mL), (p<0.001). There was a good correlation between the log serum level of anti-agalactosyl IgG antibodies and IgM-RF (r=0.92, p<0.001), anti-CCP antibodies and IgM-RF (r=0.49, p<0.001), and anti-agalactosyl IgG antibodies and anti-CCP antibodies (r=0.55, p<0.001). The sensitivity and specificity in the diagnosis of RA was 88.00% and 96.00% for anti-agalactosyl IgG antibodies, 90.00% and 99.00% for anti-CCP antibodies, and 91.00% and 95.00% for IgM-RF, respectively. The serum level of anti-agalactosyl IgG antibodies was significantly higher in RA than in SLE, SSc, and healthy controls. There was a good correlation between serum levels of anti-agalactosyl IgG antibodies, anti-CCP antibodies, and IgM-RF. These three tests had comparable sensitivity and specificity. © 2009 Clinical Rheumatology. |
format |
Journal |
author |
Worawit Louthrenoo Nuntana Kasitanon Ramjai Wichainun Suparaporn Wangkaew Waraporn Sukitawut Shoji Kuwata Fujio Takeuchi |
author_facet |
Worawit Louthrenoo Nuntana Kasitanon Ramjai Wichainun Suparaporn Wangkaew Waraporn Sukitawut Shoji Kuwata Fujio Takeuchi |
author_sort |
Worawit Louthrenoo |
title |
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
title_short |
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
title_full |
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
title_fullStr |
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
title_full_unstemmed |
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
title_sort |
anti-agalactosyl igg antibodies in thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950614799&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51102 |
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1681423709221421056 |