A chewable pediatric fixed-dose combination tablet of stavudine, lamivudine, and nevirapine: Pharmacokinetics and safety compared with the individual liquid formulations in human immunodeficiency virus-infected children in Thailand

• Main Authors: Nirun Vanprapar, Tim R. Cressey, Kulkanya Chokephaibulkit, Petronella Muresan, Nottasorn Plipat, Virat Sirisanthana, Wasana Prasitsuebsai, Suchat Hongsiriwan, Tawee Chotpitayasunondh, Achara Eksaengsri, Maripat Toye, Mary Elizabeth Smith, Kenneth McIntosh, Edmund Capparelli, Ram Yogev
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957278518&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51139
• Institution: Chiang Mai University

Background: Pediatric fixed-dose combinations (FDCs) are needed to facilitate antiretroviral therapy in children. We evaluated the relative bioavailability, safety, and therapeutic adequacy of a novel chewable pediatric FDC tablet of stavudine (7 mg), lamivudine (30 mg), and nevirapine (50 mg), refe...