Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes

Gallidermin (Gdm) loaded in anionic niosomes composed of Tween 61/CHL/DP (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). This formulation gave antibacterial activity against Propionibacterium acnes and Staphylococcus aureus with the MIC and MBC of 3.75 and 7.5; 7.5 and 15μg/μ...

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Main Authors: Aranya Manosroi, Penpan Khanrin, Warangkana Lohcharoenkal, Rolf G. Werner, Friedrich Götz, Worapaka Manosroi, Jiradej Manosroi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51154
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spelling th-cmuir.6653943832-511542018-09-04T04:52:37Z Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes Aranya Manosroi Penpan Khanrin Warangkana Lohcharoenkal Rolf G. Werner Friedrich Götz Worapaka Manosroi Jiradej Manosroi Pharmacology, Toxicology and Pharmaceutics Gallidermin (Gdm) loaded in anionic niosomes composed of Tween 61/CHL/DP (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). This formulation gave antibacterial activity against Propionibacterium acnes and Staphylococcus aureus with the MIC and MBC of 3.75 and 7.5; 7.5 and 15μg/μl, respectively. Gdm loaded in niosomes was more chemically stable than Gdm in aqueous solution of about 1.5 times. Gdm loaded and unloaded in niosomes were not found in the receiver solution investigated by vertical Franz diffusion cells at 37°C for 6h. Gdm loaded in niosomes showed higher cumulative amounts in viable epidermis and dermis (VED) of rat skin of about 2 times more than unloaded Gdm. Gdm loaded in niosomes and incorporated in gel exhibited the highest cumulative amounts (82.42±9.28μgcm-2) and fluxes (13.74±1.55μgcm-2h-1) in stratum corneum (SC) and comparative cumulative amounts (183.16±30.32μgcm-2) and fluxes (25.74±5.05μgcm-2h-1) in VED to the unloaded Gdm incorporated in gel. This study has suggested that Gdm loaded in anionic niosomes and incorporated in gel is the superior topical antibacterial formulation because of the high accumulation in the skin with no risk of systemic effect. © 2010 Elsevier B.V. 2018-09-04T04:52:37Z 2018-09-04T04:52:37Z 2010-06-01 Journal 03785173 2-s2.0-77952726024 10.1016/j.ijpharm.2010.03.064 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952726024&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51154
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Aranya Manosroi
Penpan Khanrin
Warangkana Lohcharoenkal
Rolf G. Werner
Friedrich Götz
Worapaka Manosroi
Jiradej Manosroi
Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
description Gallidermin (Gdm) loaded in anionic niosomes composed of Tween 61/CHL/DP (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). This formulation gave antibacterial activity against Propionibacterium acnes and Staphylococcus aureus with the MIC and MBC of 3.75 and 7.5; 7.5 and 15μg/μl, respectively. Gdm loaded in niosomes was more chemically stable than Gdm in aqueous solution of about 1.5 times. Gdm loaded and unloaded in niosomes were not found in the receiver solution investigated by vertical Franz diffusion cells at 37°C for 6h. Gdm loaded in niosomes showed higher cumulative amounts in viable epidermis and dermis (VED) of rat skin of about 2 times more than unloaded Gdm. Gdm loaded in niosomes and incorporated in gel exhibited the highest cumulative amounts (82.42±9.28μgcm-2) and fluxes (13.74±1.55μgcm-2h-1) in stratum corneum (SC) and comparative cumulative amounts (183.16±30.32μgcm-2) and fluxes (25.74±5.05μgcm-2h-1) in VED to the unloaded Gdm incorporated in gel. This study has suggested that Gdm loaded in anionic niosomes and incorporated in gel is the superior topical antibacterial formulation because of the high accumulation in the skin with no risk of systemic effect. © 2010 Elsevier B.V.
format Journal
author Aranya Manosroi
Penpan Khanrin
Warangkana Lohcharoenkal
Rolf G. Werner
Friedrich Götz
Worapaka Manosroi
Jiradej Manosroi
author_facet Aranya Manosroi
Penpan Khanrin
Warangkana Lohcharoenkal
Rolf G. Werner
Friedrich Götz
Worapaka Manosroi
Jiradej Manosroi
author_sort Aranya Manosroi
title Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
title_short Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
title_full Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
title_fullStr Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
title_full_unstemmed Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
title_sort transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952726024&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51154
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