Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However,...
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th-cmuir.6653943832-511552018-09-04T04:52:47Z Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line Supachai Yodkeeree Chadarat Ampasavate Bokyung Sung Bharat B. Aggarwal Pornngarm Limtrakul Pharmacology, Toxicology and Pharmaceutics Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However, the molecular mechanism by which DMC has anti-metastasis activity in breast cancer cells remains poorly understood. Here, we report for the first time that DMC inhibited adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. For cancer cell migration and invasion, extracellular matrix (ECM) degradation processes are required. MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation-associated proteins including matrix metalloproteinase-9 (MMP-9), membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase plasminogen activator (uPA) and uPA receptor (uPAR), while the level of uPA inhibitor (PAI-1) was up-regulated. Moreover, DMC also reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and chemokine receptor 4, (CXCR4), which is involved in modulation of the tumor metastasis process. We also found that DMC treatment inhibited the DNA binding activity of nuclear factor-kappa B (NF-κB), which is known to mediate the expression of MMPs, uPA, uPAR, ICAM-1, and CXCR4. These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-κB in MDA-MB-231 cells. © 2009 Elsevier B.V. All rights reserved. 2018-09-04T04:52:47Z 2018-09-04T04:52:47Z 2010-02-10 Journal 00142999 2-s2.0-73449138207 10.1016/j.ejphar.2009.09.052 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73449138207&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51155 |
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Pharmacology, Toxicology and Pharmaceutics Supachai Yodkeeree Chadarat Ampasavate Bokyung Sung Bharat B. Aggarwal Pornngarm Limtrakul Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
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Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However, the molecular mechanism by which DMC has anti-metastasis activity in breast cancer cells remains poorly understood. Here, we report for the first time that DMC inhibited adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. For cancer cell migration and invasion, extracellular matrix (ECM) degradation processes are required. MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation-associated proteins including matrix metalloproteinase-9 (MMP-9), membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase plasminogen activator (uPA) and uPA receptor (uPAR), while the level of uPA inhibitor (PAI-1) was up-regulated. Moreover, DMC also reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and chemokine receptor 4, (CXCR4), which is involved in modulation of the tumor metastasis process. We also found that DMC treatment inhibited the DNA binding activity of nuclear factor-kappa B (NF-κB), which is known to mediate the expression of MMPs, uPA, uPAR, ICAM-1, and CXCR4. These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-κB in MDA-MB-231 cells. © 2009 Elsevier B.V. All rights reserved. |
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author |
Supachai Yodkeeree Chadarat Ampasavate Bokyung Sung Bharat B. Aggarwal Pornngarm Limtrakul |
author_facet |
Supachai Yodkeeree Chadarat Ampasavate Bokyung Sung Bharat B. Aggarwal Pornngarm Limtrakul |
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Supachai Yodkeeree |
title |
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
title_short |
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
title_full |
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
title_fullStr |
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
title_full_unstemmed |
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line |
title_sort |
demethoxycurcumin suppresses migration and invasion of mda-mb-231 human breast cancer cell line |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73449138207&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51155 |
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