Cytotoxicity of extracts from fruit plants against leukemic cell lines

This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leave...

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Main Authors:	Chadarat Ampasavate, Siriporn Okonogi, Songyot Anuchapreeda
Format:	Journal
Published:	2018
Subjects:	Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77953654344&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51157
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-51157
record_format	dspace
spelling	th-cmuir.6653943832-511572018-09-04T04:52:51Z Cytotoxicity of extracts from fruit plants against leukemic cell lines Chadarat Ampasavate Siriporn Okonogi Songyot Anuchapreeda Pharmacology, Toxicology and Pharmaceutics This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leaves, mangosteen peels, and wampee leaves) had strong cytotoxic effects on K562, U937, and Molt4 cells. The IC50 values of kaffir lime leaves on those cells were 26.1, 9.0 and 11.9 μg/ml respectively, whereas those of mangosteen peel were 23.6, 4.5 and 10.1 μg/ml, and those of wampee leaves were 71.9, 13 and 70.4 μg/ml. Furthermore, pomegranate peel extract had a potent cytotoxic effect on HL60 cells (IC50 of 8.0 μg/ml), but was non-toxic to normal PBMCs, indicating that as a potential source of antileukemic agents. © 2010 Academic Journals. 2018-09-04T04:52:51Z 2018-09-04T04:52:51Z 2010-01-01 Journal 19960816 2-s2.0-77953654344 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77953654344&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51157
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Pharmacology, Toxicology and Pharmaceutics Chadarat Ampasavate Siriporn Okonogi Songyot Anuchapreeda Cytotoxicity of extracts from fruit plants against leukemic cell lines
description	This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leaves, mangosteen peels, and wampee leaves) had strong cytotoxic effects on K562, U937, and Molt4 cells. The IC50 values of kaffir lime leaves on those cells were 26.1, 9.0 and 11.9 μg/ml respectively, whereas those of mangosteen peel were 23.6, 4.5 and 10.1 μg/ml, and those of wampee leaves were 71.9, 13 and 70.4 μg/ml. Furthermore, pomegranate peel extract had a potent cytotoxic effect on HL60 cells (IC50 of 8.0 μg/ml), but was non-toxic to normal PBMCs, indicating that as a potential source of antileukemic agents. © 2010 Academic Journals.
format	Journal
author	Chadarat Ampasavate Siriporn Okonogi Songyot Anuchapreeda
author_facet	Chadarat Ampasavate Siriporn Okonogi Songyot Anuchapreeda
author_sort	Chadarat Ampasavate
title	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_short	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_full	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_fullStr	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_full_unstemmed	Cytotoxicity of extracts from fruit plants against leukemic cell lines
title_sort	cytotoxicity of extracts from fruit plants against leukemic cell lines
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77953654344&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51157
_version_	1681423719164018688

Cytotoxicity of extracts from fruit plants against leukemic cell lines

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