A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect

• Main Authors: Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Ohki Higuchi, Fumiko Kimura, Teruo Miyazawa
• 格式: 雜誌
• 出版: 2018
• 主題: Agricultural and Biological Sciences; Chemistry; Medicine
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861573909&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51237

Mulberry 1-deoxynojirimycin (DNJ), a potent α-glycosidase inhibitor, has therapeutic potency in the suppression of postprandial blood glucose levels thereby possibly preventing diabetes mellitus. However, DNJ has a relatively short half-life in vivo (about 2 h). Therefore, several doses of mulberry...