Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale

The essential oil of the leaves Solanum spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. ( E)-Phytol (48.10%), n-hexadecanoic acid (7.34%),...

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Main Authors: Sukanya Keawsa-ard, Boonsom Liawruangrath, Saisunee Liawruangrath, Aphiwat Teerawutgulrag, Stephen G. Pyne
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51259
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spelling th-cmuir.6653943832-512592018-09-04T06:13:14Z Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale Sukanya Keawsa-ard Boonsom Liawruangrath Saisunee Liawruangrath Aphiwat Teerawutgulrag Stephen G. Pyne Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics The essential oil of the leaves Solanum spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. ( E)-Phytol (48.10%), n-hexadecanoic acid (7.34%), β-selinene (3.67%), α-selinene (2.74%), octadecanoic acid (2.12%) and hexahydrofarnesyl acetone (2.00%) were the major components of this oil. The antioxidant activity of the essential oil was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. The oil exhibited week antioxidant activity with an IC50 of 41.89 mg/mL. The essential oil showed significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with MIC values of 43.0 μg/mL and 21.5 μg/mL, respectively. It also showed significant cytotoxicity against KB (oral cancer), MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 26.42, 19.69, and 24.02 μg/mL, respectively. 2018-09-04T05:59:34Z 2018-09-04T05:59:34Z 2012-08-13 Journal 15559475 1934578X 2-s2.0-84864700550 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864700550&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51259
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
Sukanya Keawsa-ard
Boonsom Liawruangrath
Saisunee Liawruangrath
Aphiwat Teerawutgulrag
Stephen G. Pyne
Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
description The essential oil of the leaves Solanum spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. ( E)-Phytol (48.10%), n-hexadecanoic acid (7.34%), β-selinene (3.67%), α-selinene (2.74%), octadecanoic acid (2.12%) and hexahydrofarnesyl acetone (2.00%) were the major components of this oil. The antioxidant activity of the essential oil was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. The oil exhibited week antioxidant activity with an IC50 of 41.89 mg/mL. The essential oil showed significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with MIC values of 43.0 μg/mL and 21.5 μg/mL, respectively. It also showed significant cytotoxicity against KB (oral cancer), MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 26.42, 19.69, and 24.02 μg/mL, respectively.
format Journal
author Sukanya Keawsa-ard
Boonsom Liawruangrath
Saisunee Liawruangrath
Aphiwat Teerawutgulrag
Stephen G. Pyne
author_facet Sukanya Keawsa-ard
Boonsom Liawruangrath
Saisunee Liawruangrath
Aphiwat Teerawutgulrag
Stephen G. Pyne
author_sort Sukanya Keawsa-ard
title Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
title_short Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
title_full Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
title_fullStr Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
title_full_unstemmed Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale
title_sort chemical constituents and antioxidant and biological activities of the essential oil from leaves of solanum spirale
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864700550&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51259
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