Chemical Constituents from the Roots of Clausena excavata and Their Cytotoxicity

• Main Authors: Tawanun Sripisut, Sarot Cheenpracha, Thunwadee Ritthiwigrom, Uma Prawat, Surat Laphookhieo
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865399055&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51267
• Institution: Chiang Mai University

Six coumarins (1-6) and twelve alkaloids (7-18) were isolated from the roots of Clausena excavata. Their structures were elucidated on the basis of spectroscopic methods. This is the first report on the isolation of compounds 1, 7 and 17 from C. excavata. Compound 1 is also the first example of an unsymmetrical dimer coumarin isolated from Clausena species. The completed assignment of13C NMR spectral data of 1 as well as HMBC spectral data is also reported here for the first time. Compounds 2-7, 11-16 and 18 were evaluated for their cytotoxicity against three human cancer cell lines, oral cavity cancer (KB), breast cancer (MCF7) and small cell lung cancer (NCI-H187). The results showed that compounds 4, 11 and 18 exhibited highest cytotoxicity against KB, MCF7 and NCI-H187 cell lines with IC50 values of5.95, 3.76 and 5.65 μg/mL, respectively. © 2012 Reproduction is free for scientific studies.