Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells

• Main Authors: Kumiko Ogawa, Pornsiri Pitchakarn, Shugo Suzuki, Teera Chewonarin, Mingxi Tang, Seishiro Takahashi, Aya Naiki-Ito, Shinya Sato, Satoru Takahashi, Makoto Asamoto, Tomoyuki Shirai
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860250064&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51405
• Institution: Chiang Mai University

To reduce cancer mortality, understanding of mechanisms of cancer metastasis is crucial. We have established six rat hepatocellular carcinoma (HCC) cell lines, which exhibit differing metastatic potential to the lung after inoculation into the tail veins of nude mice. In the present experiment, we i...