Bioactive carbazole alkaloids from Clausena wallichii roots

Bioactive carbazole alkaloids from Clausena wallichii roots

Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus...

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Main Authors: Wisanu Maneerat, Thunwadee Ritthiwigrom, Sarot Cheenpracha, Trinop Promgool, Kulsiri Yossathera, Suwanna Deachathai, Wong Phakhodee, Surat Laphookhieo
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860341545&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51406
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Institution: Chiang Mai University
id th-cmuir.6653943832-51406
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spelling th-cmuir.6653943832-514062018-09-04T06:13:25Z Bioactive carbazole alkaloids from Clausena wallichii roots Wisanu Maneerat Thunwadee Ritthiwigrom Sarot Cheenpracha Trinop Promgool Kulsiri Yossathera Suwanna Deachathai Wong Phakhodee Surat Laphookhieo Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy. 2018-09-04T06:01:22Z 2018-09-04T06:01:22Z 2012-04-27 Journal 15206025 01633864 2-s2.0-84860341545 10.1021/np3000365 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860341545&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51406
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Wisanu Maneerat
Thunwadee Ritthiwigrom
Sarot Cheenpracha
Trinop Promgool
Kulsiri Yossathera
Suwanna Deachathai
Wong Phakhodee
Surat Laphookhieo
Bioactive carbazole alkaloids from Clausena wallichii roots
description Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy.
format Journal
author Wisanu Maneerat
Thunwadee Ritthiwigrom
Sarot Cheenpracha
Trinop Promgool
Kulsiri Yossathera
Suwanna Deachathai
Wong Phakhodee
Surat Laphookhieo
author_facet Wisanu Maneerat
Thunwadee Ritthiwigrom
Sarot Cheenpracha
Trinop Promgool
Kulsiri Yossathera
Suwanna Deachathai
Wong Phakhodee
Surat Laphookhieo
author_sort Wisanu Maneerat
title Bioactive carbazole alkaloids from Clausena wallichii roots
title_short Bioactive carbazole alkaloids from Clausena wallichii roots
title_full Bioactive carbazole alkaloids from Clausena wallichii roots
title_fullStr Bioactive carbazole alkaloids from Clausena wallichii roots
title_full_unstemmed Bioactive carbazole alkaloids from Clausena wallichii roots
title_sort bioactive carbazole alkaloids from clausena wallichii roots
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860341545&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51406
_version_ 1681423763988545536

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