Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D

A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a s...

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Main Authors: Manatsawee Manopunya, Prapaporn Suprasert
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51419
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spelling th-cmuir.6653943832-514192018-09-04T06:12:27Z Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D Manatsawee Manopunya Prapaporn Suprasert Biochemistry, Genetics and Molecular Biology Medicine A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a salvage setting was unclear. To evaluate the efficacy and safety of the 5 FU plus Act D regimen utilized in this condition, all GTN patients resistant to at least three previous chemotherapy regimens who received the 5 FU plus Act D regimen between August 2009 and January 2011 at Chiang Mai University Hospital were reviewed. There were five cases who met the criteria. Four of those patients were in FIGO stage III to IV with a WHO scoring of more than 12. The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity. 2018-09-04T06:01:42Z 2018-09-04T06:01:42Z 2012-01-01 Journal 2476762X 15137368 2-s2.0-84864867653 10.7314/APJCP.2012.13.1.387 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864867653&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51419
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Manatsawee Manopunya
Prapaporn Suprasert
Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
description A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a salvage setting was unclear. To evaluate the efficacy and safety of the 5 FU plus Act D regimen utilized in this condition, all GTN patients resistant to at least three previous chemotherapy regimens who received the 5 FU plus Act D regimen between August 2009 and January 2011 at Chiang Mai University Hospital were reviewed. There were five cases who met the criteria. Four of those patients were in FIGO stage III to IV with a WHO scoring of more than 12. The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity.
format Journal
author Manatsawee Manopunya
Prapaporn Suprasert
author_facet Manatsawee Manopunya
Prapaporn Suprasert
author_sort Manatsawee Manopunya
title Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
title_short Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
title_full Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
title_fullStr Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
title_full_unstemmed Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D
title_sort resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin d
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864867653&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51419
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