Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers

We designed an open-label, randomized two-phase crossover study to investigate the antioxidant effects after single and multiple doses of a coffee enema versus coffee consumed orally. Eleven healthy subjects were randomly assigned to either receive a coffee enema (3 times weekly for 6 visits) or con...

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Main Authors: S. Teekachunhatean, N. Tosri, C. Sangdee, R. Wongpoomchai, W. Ruangyuttikarn, C. Puaninta, S. Srichairatanakool
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51689
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-516892018-09-04T06:13:17Z Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers S. Teekachunhatean N. Tosri C. Sangdee R. Wongpoomchai W. Ruangyuttikarn C. Puaninta S. Srichairatanakool Environmental Science Pharmacology, Toxicology and Pharmaceutics We designed an open-label, randomized two-phase crossover study to investigate the antioxidant effects after single and multiple doses of a coffee enema versus coffee consumed orally. Eleven healthy subjects were randomly assigned to either receive a coffee enema (3 times weekly for 6 visits) or consume ready-to-drink coffee (2 times daily for 11 days). After a washout period, subjects were switched to receive the alternate coffee procedure. Blood samples were collected at specific time points for the determination of serum levels of glutathione (GSH), malondialdehyde (MDA) and trolox equivalent antioxidant capacity (TEAC). The findings showed that either single or multiple administrations of the coffee enema or orally consumed coffee doses seemed not to produce any beneficial effects to enhance serum GSH levels or to decrease serum MDA levels over the study period of 12 days. In contrast, mean serum TEAC levels at day 12 after the coffee enema and at days 6 and 12 after oral coffee consumption were significantly reduced from their corresponding baseline values. Thus, no beneficial effects with respect to an enhancement of serum GSH and TEAC levels or a decrease in serum MDA concentrations were demonstrated after coffee enema or orally consumed ready-to-drink coffee. © The Author(s) 2012. 2018-09-04T06:06:21Z 2018-09-04T06:06:21Z 2012-07-01 Journal 14770903 09603271 2-s2.0-84864123430 10.1177/0960327111432499 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864123430&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51689
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Environmental Science
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Environmental Science
Pharmacology, Toxicology and Pharmaceutics
S. Teekachunhatean
N. Tosri
C. Sangdee
R. Wongpoomchai
W. Ruangyuttikarn
C. Puaninta
S. Srichairatanakool
Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
description We designed an open-label, randomized two-phase crossover study to investigate the antioxidant effects after single and multiple doses of a coffee enema versus coffee consumed orally. Eleven healthy subjects were randomly assigned to either receive a coffee enema (3 times weekly for 6 visits) or consume ready-to-drink coffee (2 times daily for 11 days). After a washout period, subjects were switched to receive the alternate coffee procedure. Blood samples were collected at specific time points for the determination of serum levels of glutathione (GSH), malondialdehyde (MDA) and trolox equivalent antioxidant capacity (TEAC). The findings showed that either single or multiple administrations of the coffee enema or orally consumed coffee doses seemed not to produce any beneficial effects to enhance serum GSH levels or to decrease serum MDA levels over the study period of 12 days. In contrast, mean serum TEAC levels at day 12 after the coffee enema and at days 6 and 12 after oral coffee consumption were significantly reduced from their corresponding baseline values. Thus, no beneficial effects with respect to an enhancement of serum GSH and TEAC levels or a decrease in serum MDA concentrations were demonstrated after coffee enema or orally consumed ready-to-drink coffee. © The Author(s) 2012.
format Journal
author S. Teekachunhatean
N. Tosri
C. Sangdee
R. Wongpoomchai
W. Ruangyuttikarn
C. Puaninta
S. Srichairatanakool
author_facet S. Teekachunhatean
N. Tosri
C. Sangdee
R. Wongpoomchai
W. Ruangyuttikarn
C. Puaninta
S. Srichairatanakool
author_sort S. Teekachunhatean
title Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
title_short Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
title_full Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
title_fullStr Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
title_full_unstemmed Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers
title_sort antioxidant effects after coffee enema or oral coffee consumption in healthy thai male volunteers
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864123430&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51689
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