Once- versus twice-daily lopinavir/ritonavir tablets in virologically suppressed, HIV-infected, treatment-experienced children: Comparative pharmacokinetics and virological outcome after switching to once-daily lopinavir/ritonavir

• Main Authors: Kulkanya Chokephaibulkit, Maneeratn Nuntarukchaikul, Wanatpreeya Phongsamart, Orasri Wittawatmongkol, Keswadee Lapphra, Nirun Vanprapar, Tim R. Cressey
• Format: Journal
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84869462249&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51829
• Institution: Chiang Mai University

Objectives: Data on lopinavir/ritonavir tablets administered once daily in children are limited. We compared the pharmacokinetics (PK) of lopinavir/ritonavir twice daily versus once daily in virologically suppressed, HIV-infected children, and assessed the virological outcome, at 48 weeks, in childr...