Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer

The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a...

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Main Authors: Yupada Pongprot, Rekwan Sittiwangkul, Pimlak Charoenkwan, Suchaya Silvilairat
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834
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spelling th-cmuir.6653943832-518342018-09-04T06:10:03Z Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer Yupada Pongprot Rekwan Sittiwangkul Pimlak Charoenkwan Suchaya Silvilairat Medicine The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a cross-sectional case study of systolic, diastolic function and tissue Doppler imaging by echocardiography in children with cancer who received a certain cumulative dose of doxorubicin. Blood levels for NT-pro-BNP, cardiac troponin T, and CK-MB were analyzed within 6 hours of the cardiac study. Of 30 patients, 5 (16.7%) had LV dysfunction with an abnormally high NT-pro-BNP level of 363±78 pg/mL, whereas patients with normal LV function had an NT-pro-BNP level of 148±173 pg/mL (P=0.012). The NT-pro-BNP level not only inversely correlated with fractional shortening (r=-0.43, P=0.017) and ejection fraction (r=-0.45, P=0.013) but also correlated with mitral deceleration time (r=0.41, P=0.021) and a cumulative dose of doxorubicin (r=0.44, P=0.014). For tissue Doppler imaging, NT-pro-BNP correlated with a peak systolic velocity at the myocardial segment (Sm) (r=-0.40, P=0.027). NT-pro-BNP is a sensitive test and has a moderate relationship with the LV systolic and diastolic function, thus making it a useful cardiac marker for the monitoring of early anthracycline cardiotoxicity. Copyright © 2012 by Lippincott Williams & Wilkins. 2018-09-04T06:10:03Z 2018-09-04T06:10:03Z 2012-11-01 Journal 15363678 10774114 2-s2.0-84868632918 10.1097/MPH.0b013e31826faf44 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868632918&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Yupada Pongprot
Rekwan Sittiwangkul
Pimlak Charoenkwan
Suchaya Silvilairat
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
description The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a cross-sectional case study of systolic, diastolic function and tissue Doppler imaging by echocardiography in children with cancer who received a certain cumulative dose of doxorubicin. Blood levels for NT-pro-BNP, cardiac troponin T, and CK-MB were analyzed within 6 hours of the cardiac study. Of 30 patients, 5 (16.7%) had LV dysfunction with an abnormally high NT-pro-BNP level of 363±78 pg/mL, whereas patients with normal LV function had an NT-pro-BNP level of 148±173 pg/mL (P=0.012). The NT-pro-BNP level not only inversely correlated with fractional shortening (r=-0.43, P=0.017) and ejection fraction (r=-0.45, P=0.013) but also correlated with mitral deceleration time (r=0.41, P=0.021) and a cumulative dose of doxorubicin (r=0.44, P=0.014). For tissue Doppler imaging, NT-pro-BNP correlated with a peak systolic velocity at the myocardial segment (Sm) (r=-0.40, P=0.027). NT-pro-BNP is a sensitive test and has a moderate relationship with the LV systolic and diastolic function, thus making it a useful cardiac marker for the monitoring of early anthracycline cardiotoxicity. Copyright © 2012 by Lippincott Williams & Wilkins.
format Journal
author Yupada Pongprot
Rekwan Sittiwangkul
Pimlak Charoenkwan
Suchaya Silvilairat
author_facet Yupada Pongprot
Rekwan Sittiwangkul
Pimlak Charoenkwan
Suchaya Silvilairat
author_sort Yupada Pongprot
title Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
title_short Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
title_full Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
title_fullStr Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
title_full_unstemmed Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
title_sort use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868632918&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834
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