Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer
The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868632918&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-51834 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-518342018-09-04T06:10:03Z Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer Yupada Pongprot Rekwan Sittiwangkul Pimlak Charoenkwan Suchaya Silvilairat Medicine The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a cross-sectional case study of systolic, diastolic function and tissue Doppler imaging by echocardiography in children with cancer who received a certain cumulative dose of doxorubicin. Blood levels for NT-pro-BNP, cardiac troponin T, and CK-MB were analyzed within 6 hours of the cardiac study. Of 30 patients, 5 (16.7%) had LV dysfunction with an abnormally high NT-pro-BNP level of 363±78 pg/mL, whereas patients with normal LV function had an NT-pro-BNP level of 148±173 pg/mL (P=0.012). The NT-pro-BNP level not only inversely correlated with fractional shortening (r=-0.43, P=0.017) and ejection fraction (r=-0.45, P=0.013) but also correlated with mitral deceleration time (r=0.41, P=0.021) and a cumulative dose of doxorubicin (r=0.44, P=0.014). For tissue Doppler imaging, NT-pro-BNP correlated with a peak systolic velocity at the myocardial segment (Sm) (r=-0.40, P=0.027). NT-pro-BNP is a sensitive test and has a moderate relationship with the LV systolic and diastolic function, thus making it a useful cardiac marker for the monitoring of early anthracycline cardiotoxicity. Copyright © 2012 by Lippincott Williams & Wilkins. 2018-09-04T06:10:03Z 2018-09-04T06:10:03Z 2012-11-01 Journal 15363678 10774114 2-s2.0-84868632918 10.1097/MPH.0b013e31826faf44 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868632918&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Medicine |
spellingShingle |
Medicine Yupada Pongprot Rekwan Sittiwangkul Pimlak Charoenkwan Suchaya Silvilairat Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
description |
The aim of this study was to evaluate N-terminal probrain natriuretic peptides (NT-pro-BNP), cardiac troponin T, and creatinine kinase, MB isoenzyme (CK-MB) in the determination of subclinical left ventricular (LV) dysfunction by echocardiography in patients treated with doxorubicin. We performed a cross-sectional case study of systolic, diastolic function and tissue Doppler imaging by echocardiography in children with cancer who received a certain cumulative dose of doxorubicin. Blood levels for NT-pro-BNP, cardiac troponin T, and CK-MB were analyzed within 6 hours of the cardiac study. Of 30 patients, 5 (16.7%) had LV dysfunction with an abnormally high NT-pro-BNP level of 363±78 pg/mL, whereas patients with normal LV function had an NT-pro-BNP level of 148±173 pg/mL (P=0.012). The NT-pro-BNP level not only inversely correlated with fractional shortening (r=-0.43, P=0.017) and ejection fraction (r=-0.45, P=0.013) but also correlated with mitral deceleration time (r=0.41, P=0.021) and a cumulative dose of doxorubicin (r=0.44, P=0.014). For tissue Doppler imaging, NT-pro-BNP correlated with a peak systolic velocity at the myocardial segment (Sm) (r=-0.40, P=0.027). NT-pro-BNP is a sensitive test and has a moderate relationship with the LV systolic and diastolic function, thus making it a useful cardiac marker for the monitoring of early anthracycline cardiotoxicity. Copyright © 2012 by Lippincott Williams & Wilkins. |
format |
Journal |
author |
Yupada Pongprot Rekwan Sittiwangkul Pimlak Charoenkwan Suchaya Silvilairat |
author_facet |
Yupada Pongprot Rekwan Sittiwangkul Pimlak Charoenkwan Suchaya Silvilairat |
author_sort |
Yupada Pongprot |
title |
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
title_short |
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
title_full |
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
title_fullStr |
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
title_full_unstemmed |
Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
title_sort |
use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868632918&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51834 |
_version_ |
1681423841356677120 |