Cardioprotective effects of incretin during ischaemia-reperfusion
Incretin is a gut derived peptide hormone secreted in the intestine after food ingestion, and is degraded rapidly after secretion by dipeptidyl peptidase (DPP)-4. Incretin-based therapy, such as glucagon-like peptide (GLP)-1 and the DPP-4 inhibitor, has been proposed as a new therapeutic approach fo...
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th-cmuir.6653943832-518402018-09-04T06:10:13Z Cardioprotective effects of incretin during ischaemia-reperfusion Kroekkiat Chinda Siriporn Chattipakorn Nipon Chattipakorn Medicine Incretin is a gut derived peptide hormone secreted in the intestine after food ingestion, and is degraded rapidly after secretion by dipeptidyl peptidase (DPP)-4. Incretin-based therapy, such as glucagon-like peptide (GLP)-1 and the DPP-4 inhibitor, has been proposed as a new therapeutic approach for the treatment of type 2 diabetic patients. In the past few years, growing evidence also demonstrated the cardioprotective effects of incretin-based therapy, especially during ischaemia-reperfusion (I/R) injury in both the animal models and in clinical studies. However, inconsistent reports exist regarding the use of these pharmacological interventions. In this article, a comprehensive review regarding both basic and clinical studies reporting the effects of GLP-1 and DPP-4 inhibitors on I/R hearts is presented and discussed. The consistent findings as well as controversial results are summarised, focusing on the effects of incretin on the infarct size, left ventricular function and haemodynamic improvement during an I/R injury. © The Author(s) 2012. 2018-09-04T06:10:13Z 2018-09-04T06:10:13Z 2012-10-01 Journal 17528984 14791641 2-s2.0-84864380749 10.1177/1479164112440816 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864380749&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51840 |
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Medicine Kroekkiat Chinda Siriporn Chattipakorn Nipon Chattipakorn Cardioprotective effects of incretin during ischaemia-reperfusion |
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Incretin is a gut derived peptide hormone secreted in the intestine after food ingestion, and is degraded rapidly after secretion by dipeptidyl peptidase (DPP)-4. Incretin-based therapy, such as glucagon-like peptide (GLP)-1 and the DPP-4 inhibitor, has been proposed as a new therapeutic approach for the treatment of type 2 diabetic patients. In the past few years, growing evidence also demonstrated the cardioprotective effects of incretin-based therapy, especially during ischaemia-reperfusion (I/R) injury in both the animal models and in clinical studies. However, inconsistent reports exist regarding the use of these pharmacological interventions. In this article, a comprehensive review regarding both basic and clinical studies reporting the effects of GLP-1 and DPP-4 inhibitors on I/R hearts is presented and discussed. The consistent findings as well as controversial results are summarised, focusing on the effects of incretin on the infarct size, left ventricular function and haemodynamic improvement during an I/R injury. © The Author(s) 2012. |
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author |
Kroekkiat Chinda Siriporn Chattipakorn Nipon Chattipakorn |
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Kroekkiat Chinda Siriporn Chattipakorn Nipon Chattipakorn |
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Kroekkiat Chinda |
title |
Cardioprotective effects of incretin during ischaemia-reperfusion |
title_short |
Cardioprotective effects of incretin during ischaemia-reperfusion |
title_full |
Cardioprotective effects of incretin during ischaemia-reperfusion |
title_fullStr |
Cardioprotective effects of incretin during ischaemia-reperfusion |
title_full_unstemmed |
Cardioprotective effects of incretin during ischaemia-reperfusion |
title_sort |
cardioprotective effects of incretin during ischaemia-reperfusion |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864380749&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51840 |
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