Nevirapine exposure with WHO pediatric weight band dosing: Enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience

• Main Authors: Mina Nikanjam, Desiré Kabamba, Tim R. Cressey, David Burger, Francesca T. Aweek, Edward P. Acosta, Stephen A. Spector, Edmund V. Capparelli
• 格式: 雜誌
• 出版: 2018
• 主題: Medicine; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866307391&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51844

Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) used worldwide as part of combination antiretroviral therapy in infants and children to treat HIV infection. Dosing based on either weight or body surface area has been approved by the U.S. Food and Drug Administration (FDA)...