Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission
Background: The purpose of this study was to evaluate the long-term effect of repetitive transcranial magnetic stimulation (rTMS) as adjunctive treatment in patients with partial remission of major depressive disorder. Methods: This was a 12-month, prospective, open-label study in patients meeting t...
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th-cmuir.6653943832-518562018-09-04T06:12:47Z Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission Chawanun Charnsil Sirijit Suttajit Vudhichai Boonyanaruthee Samornsri Leelarphat Medicine Neuroscience Background: The purpose of this study was to evaluate the long-term effect of repetitive transcranial magnetic stimulation (rTMS) as adjunctive treatment in patients with partial remission of major depressive disorder. Methods: This was a 12-month, prospective, open-label study in patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria for nonpsychotic major depressive disorder who responded to 8 weeks of medication treatment but did not reach remission. All patients were assigned to receive 10sessions of rTMS applied at the left dorsolateral prefrontal cortex. During the course of rTMS, the patients were still taking their usual medication. Patients were followed up for 12months to determine the long-term antidepressant effect. Results: There were nine patients (seven women and two men) who met the inclusion criteria and agreed to receive rTMS. The mean Hamilton rating scale for depression (HAM-D) score prior to treatment with rTMS was 12.89±2.15. At 12months after treatment, the mean HAM-D score was 6.45±1.67 using a Friedman test, and in patients with partial remission of major depressive disorder, the HAM-D score significantly decreased after treatment with rTMS at 12months (P=0.001). Seven patients (77.78%) had reached the stage of remission (HAM-D,8) after treating with rTMS at 12months. There were no serious adverse events. One patient had vertigo after the first session of treatment and one patient felt scalp contractions during treatment, and both fully recovered within half an hour with no medical intervention. Conclusion: For patients with major depressive disorder in partial remission, high frequency rTMS at the left dorsolateral prefrontal cortex may provide benefits in adjunctive treatment with well tolerability. Also, follow-up findings show a long duration of benefit. © 2012 Charnsil etal, publisher and licensee Dove Medical Press Ltd. 2018-09-04T06:10:36Z 2018-09-04T06:10:36Z 2012-08-29 Journal 11782021 11766328 2-s2.0-84866533909 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866533909&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51856 |
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Medicine Neuroscience Chawanun Charnsil Sirijit Suttajit Vudhichai Boonyanaruthee Samornsri Leelarphat Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
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Background: The purpose of this study was to evaluate the long-term effect of repetitive transcranial magnetic stimulation (rTMS) as adjunctive treatment in patients with partial remission of major depressive disorder. Methods: This was a 12-month, prospective, open-label study in patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria for nonpsychotic major depressive disorder who responded to 8 weeks of medication treatment but did not reach remission. All patients were assigned to receive 10sessions of rTMS applied at the left dorsolateral prefrontal cortex. During the course of rTMS, the patients were still taking their usual medication. Patients were followed up for 12months to determine the long-term antidepressant effect. Results: There were nine patients (seven women and two men) who met the inclusion criteria and agreed to receive rTMS. The mean Hamilton rating scale for depression (HAM-D) score prior to treatment with rTMS was 12.89±2.15. At 12months after treatment, the mean HAM-D score was 6.45±1.67 using a Friedman test, and in patients with partial remission of major depressive disorder, the HAM-D score significantly decreased after treatment with rTMS at 12months (P=0.001). Seven patients (77.78%) had reached the stage of remission (HAM-D,8) after treating with rTMS at 12months. There were no serious adverse events. One patient had vertigo after the first session of treatment and one patient felt scalp contractions during treatment, and both fully recovered within half an hour with no medical intervention. Conclusion: For patients with major depressive disorder in partial remission, high frequency rTMS at the left dorsolateral prefrontal cortex may provide benefits in adjunctive treatment with well tolerability. Also, follow-up findings show a long duration of benefit. © 2012 Charnsil etal, publisher and licensee Dove Medical Press Ltd. |
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Chawanun Charnsil Sirijit Suttajit Vudhichai Boonyanaruthee Samornsri Leelarphat |
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Chawanun Charnsil Sirijit Suttajit Vudhichai Boonyanaruthee Samornsri Leelarphat |
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Chawanun Charnsil |
title |
Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
title_short |
Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
title_full |
Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
title_fullStr |
Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
title_full_unstemmed |
Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
title_sort |
twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866533909&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51856 |
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