Infectious causes of posterior uveitis and panuveitis in Thailand

Purpose: To determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand. Methods: We investigated the infectious causes of uveitis involving the posterior segment of the eye by using real-time polymerase chain reaction (PCR) for cytomegalovirus (CMV), herpes simplex v...

Full description

Saved in:
Bibliographic Details
Main Authors: Natedao Kongyai, Kessara Pathanapitoon, Wasna Sirirungsi, Paradee Kunavisarut, Jolanda D F De Groot-Mijnes, Aniki Rothova
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863874814&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51870
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-51870
record_format dspace
spelling th-cmuir.6653943832-518702018-09-04T06:10:53Z Infectious causes of posterior uveitis and panuveitis in Thailand Natedao Kongyai Kessara Pathanapitoon Wasna Sirirungsi Paradee Kunavisarut Jolanda D F De Groot-Mijnes Aniki Rothova Medicine Purpose: To determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand. Methods: We investigated the infectious causes of uveitis involving the posterior segment of the eye by using real-time polymerase chain reaction (PCR) for cytomegalovirus (CMV), herpes simplex virus (HSV-1, HSV-2), varicella zoster virus and Toxoplasma gondii (T. gondii) DNA in intraocular samples of 80 human immunodeficiency virus (HIV)-negative patients. Additionally, in 61 patients, we performed Goldmann-Witmer coefficient (GWC) analysis for T. gondii. Results: Twenty-four (30%) patients with PU and/or panU had a positive PCR result. Overall, CMV was the most frequently identified organism. While CMV was the most common cause of uveitis in the patients on immunosuppressive medications for nonocular disorders, HSV was the most common cause of posterior and panuveitis in the patients not receiving such medication. In 38 PU patients, CMV was the most common detected pathogen. In 42 panU patients, CMV and HSV-2 were the most frequently identified pathogens. Out of 61 paired samples analyzed for T. gondii by GWC analysis, only 1 revealed a positive result. There was no difference in PCR results between aqueous humor and vitreous samples. Conclusions: CMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1- negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis. © Japanese Ophthalmological Society 2012. 2018-09-04T06:10:53Z 2018-09-04T06:10:53Z 2012-07-01 Journal 16132246 00215155 2-s2.0-84863874814 10.1007/s10384-012-0144-5 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863874814&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51870
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Natedao Kongyai
Kessara Pathanapitoon
Wasna Sirirungsi
Paradee Kunavisarut
Jolanda D F De Groot-Mijnes
Aniki Rothova
Infectious causes of posterior uveitis and panuveitis in Thailand
description Purpose: To determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand. Methods: We investigated the infectious causes of uveitis involving the posterior segment of the eye by using real-time polymerase chain reaction (PCR) for cytomegalovirus (CMV), herpes simplex virus (HSV-1, HSV-2), varicella zoster virus and Toxoplasma gondii (T. gondii) DNA in intraocular samples of 80 human immunodeficiency virus (HIV)-negative patients. Additionally, in 61 patients, we performed Goldmann-Witmer coefficient (GWC) analysis for T. gondii. Results: Twenty-four (30%) patients with PU and/or panU had a positive PCR result. Overall, CMV was the most frequently identified organism. While CMV was the most common cause of uveitis in the patients on immunosuppressive medications for nonocular disorders, HSV was the most common cause of posterior and panuveitis in the patients not receiving such medication. In 38 PU patients, CMV was the most common detected pathogen. In 42 panU patients, CMV and HSV-2 were the most frequently identified pathogens. Out of 61 paired samples analyzed for T. gondii by GWC analysis, only 1 revealed a positive result. There was no difference in PCR results between aqueous humor and vitreous samples. Conclusions: CMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1- negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis. © Japanese Ophthalmological Society 2012.
format Journal
author Natedao Kongyai
Kessara Pathanapitoon
Wasna Sirirungsi
Paradee Kunavisarut
Jolanda D F De Groot-Mijnes
Aniki Rothova
author_facet Natedao Kongyai
Kessara Pathanapitoon
Wasna Sirirungsi
Paradee Kunavisarut
Jolanda D F De Groot-Mijnes
Aniki Rothova
author_sort Natedao Kongyai
title Infectious causes of posterior uveitis and panuveitis in Thailand
title_short Infectious causes of posterior uveitis and panuveitis in Thailand
title_full Infectious causes of posterior uveitis and panuveitis in Thailand
title_fullStr Infectious causes of posterior uveitis and panuveitis in Thailand
title_full_unstemmed Infectious causes of posterior uveitis and panuveitis in Thailand
title_sort infectious causes of posterior uveitis and panuveitis in thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863874814&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51870
_version_ 1681423847828488192