Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand
Summary: Thailand has been greatly affected by the tuberculosis (TB) and HIV syndemic. This study aimed to determine treatment outcomes among HIV/TB co-infected patients. A retrospective cohort study was conducted at Chiang Mai University Hospital from 1 January 2000 to 31 December 2009. Of 171 pati...
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th-cmuir.6653943832-518792018-09-04T06:11:04Z Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand S. Limmahakhun R. Chaiwarith N. Nuntachit T. Sirisanthana K. Supparatpinyo Medicine Summary: Thailand has been greatly affected by the tuberculosis (TB) and HIV syndemic. This study aimed to determine treatment outcomes among HIV/TB co-infected patients. A retrospective cohort study was conducted at Chiang Mai University Hospital from 1 January 2000 to 31 December 2009. Of 171 patients, 100 patients were male (58.5%) and the mean age was 36.8 ± 8.0 years. Seventy-two patients (42.1%) had pulmonary tuberculosis. Median CD4+ count before TB treatment was 69 cells/mm3(interquartile range [IQR] 33, 151). The overall mortality was 3.5% (6 patients). Immune reconstitution inflammatory syndrome (IRIS) occurred in eight patients (6.0%). Disseminated TB infections increased risk of death (odds ratio [OR] = 2.55, 95% confidence interval [CI] 1.25, 5.18) and IRIS (OR = 9.16, 95% CI 1.67, 50.07). Initiating combination antiretroviral therapy (cART) within two months after TB treatment increased risk of IRIS (OR = 6.57, 95% CI 1.61 -26.86) and physicians caring for HIV/TB co-infected patients should be aware of this condition. 2018-09-04T06:11:04Z 2018-09-04T06:11:04Z 2012-06-01 Journal 09564624 2-s2.0-84864074000 10.1258/ijsa.2012.011291 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864074000&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51879 |
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Medicine S. Limmahakhun R. Chaiwarith N. Nuntachit T. Sirisanthana K. Supparatpinyo Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
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Summary: Thailand has been greatly affected by the tuberculosis (TB) and HIV syndemic. This study aimed to determine treatment outcomes among HIV/TB co-infected patients. A retrospective cohort study was conducted at Chiang Mai University Hospital from 1 January 2000 to 31 December 2009. Of 171 patients, 100 patients were male (58.5%) and the mean age was 36.8 ± 8.0 years. Seventy-two patients (42.1%) had pulmonary tuberculosis. Median CD4+ count before TB treatment was 69 cells/mm3(interquartile range [IQR] 33, 151). The overall mortality was 3.5% (6 patients). Immune reconstitution inflammatory syndrome (IRIS) occurred in eight patients (6.0%). Disseminated TB infections increased risk of death (odds ratio [OR] = 2.55, 95% confidence interval [CI] 1.25, 5.18) and IRIS (OR = 9.16, 95% CI 1.67, 50.07). Initiating combination antiretroviral therapy (cART) within two months after TB treatment increased risk of IRIS (OR = 6.57, 95% CI 1.61 -26.86) and physicians caring for HIV/TB co-infected patients should be aware of this condition. |
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Journal |
author |
S. Limmahakhun R. Chaiwarith N. Nuntachit T. Sirisanthana K. Supparatpinyo |
author_facet |
S. Limmahakhun R. Chaiwarith N. Nuntachit T. Sirisanthana K. Supparatpinyo |
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S. Limmahakhun |
title |
Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
title_short |
Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
title_full |
Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
title_fullStr |
Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
title_full_unstemmed |
Treatment outcomes of patients co-infected with tuberculosis and HIV at Chiang Mai university hospital, Thailand |
title_sort |
treatment outcomes of patients co-infected with tuberculosis and hiv at chiang mai university hospital, thailand |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864074000&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51879 |
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