Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women
The objective of the present paper was to determine the influence of fructooligosaccharide (FOS) on the pharmacokinetics of isoflavones in healthy postmenopausal women. The study was a fixed-sequence, two-phase, crossover study. Twelve subjects received a single oral dose of 300mL of a soy beverage....
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th-cmuir.6653943832-518922018-09-04T06:11:17Z Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women Supanimit Teekachunhatean Sujitra Techatoei Noppamas Rojanasthein Maleeya Manorot Chaichan Sangdee Medicine The objective of the present paper was to determine the influence of fructooligosaccharide (FOS) on the pharmacokinetics of isoflavones in healthy postmenopausal women. The study was a fixed-sequence, two-phase, crossover study. Twelve subjects received a single oral dose of 300mL of a soy beverage. Blood samples were collected before the dose and at 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 32h after the administration of the soy beverage. After a washout period of at least 1 week, subjects were assigned to receive oral doses of FOS, 5g each time, twice a day (after breakfast and dinner) for 14 days, followed by a single oral dose of the same soy beverage on the next day. Blood samples were then collected at the same time points mentioned previously. Plasma isoflavone concentrations were determined by HPLC. Continuous oral administrations of FOS followed by a single oral administration of soy beverage caused significant increases in C max, AUC032, and AUC0∞ of genistein and AUC032 of daidzein, comparing to those obtained following a single oral dose of soy beverage alone. Other pharmacokinetic parameters (T max and t 12 of both aglycones and AUC0∞ of daidzein) between both regimens were not significantly different. Copyright © 2012 Supanimit Teekachunhatean et al. 2018-09-04T06:11:17Z 2018-09-04T06:11:17Z 2012-05-21 Journal 17414288 1741427X 2-s2.0-84861068516 10.1155/2012/783802 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861068516&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51892 |
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Medicine Supanimit Teekachunhatean Sujitra Techatoei Noppamas Rojanasthein Maleeya Manorot Chaichan Sangdee Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
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The objective of the present paper was to determine the influence of fructooligosaccharide (FOS) on the pharmacokinetics of isoflavones in healthy postmenopausal women. The study was a fixed-sequence, two-phase, crossover study. Twelve subjects received a single oral dose of 300mL of a soy beverage. Blood samples were collected before the dose and at 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 32h after the administration of the soy beverage. After a washout period of at least 1 week, subjects were assigned to receive oral doses of FOS, 5g each time, twice a day (after breakfast and dinner) for 14 days, followed by a single oral dose of the same soy beverage on the next day. Blood samples were then collected at the same time points mentioned previously. Plasma isoflavone concentrations were determined by HPLC. Continuous oral administrations of FOS followed by a single oral administration of soy beverage caused significant increases in C max, AUC032, and AUC0∞ of genistein and AUC032 of daidzein, comparing to those obtained following a single oral dose of soy beverage alone. Other pharmacokinetic parameters (T max and t 12 of both aglycones and AUC0∞ of daidzein) between both regimens were not significantly different. Copyright © 2012 Supanimit Teekachunhatean et al. |
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Supanimit Teekachunhatean Sujitra Techatoei Noppamas Rojanasthein Maleeya Manorot Chaichan Sangdee |
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Supanimit Teekachunhatean Sujitra Techatoei Noppamas Rojanasthein Maleeya Manorot Chaichan Sangdee |
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Supanimit Teekachunhatean |
title |
Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
title_short |
Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
title_full |
Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
title_fullStr |
Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
title_full_unstemmed |
Influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
title_sort |
influence of fructooligosaccharide on pharmacokinetics of isoflavones in postmenopausal women |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861068516&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51892 |
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