The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS
Objectives: Health-related quality of life (HRQL) is an important outcome in HIV/AIDS infection and treatment. However, most existing HIV-HRQL instruments miss important issues (eg, sleeping problems, lipodystrophy). They were developed before highly active antiretroviral therapy (pre-HAART), and in...
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th-cmuir.6653943832-519072018-09-04T06:11:30Z The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS Martin Duracinsky Susan Herrmann Baiba Berzins Andrew R. Armstrong Rewa Kohli Sophie Le Coeur Assane Diouf Isabelle Fournier Mauro Schechter Olivier Chassany Medicine Objectives: Health-related quality of life (HRQL) is an important outcome in HIV/AIDS infection and treatment. However, most existing HIV-HRQL instruments miss important issues (eg, sleeping problems, lipodystrophy). They were developed before highly active antiretroviral therapy (pre-HAART), and in a single language. We sought to develop a contemporary HIV-HRQL instrument (PROQOL-HIV) in multiple languages that accounts for HAART treatment and side effects. This article details the 3-stage content validation phase of PROQOL-HIV. Methods: In stage 1, we developed a conceptual model of HIVHRQL and questionnaire item bank from thematic analysis of 152 patient interviews conducted simultaneously across 9 countries. In stage 2, pilot items were selected by an expert panel to form the pilot instrument. Stage 3 involved linguistic validation and harmonization of selected items to form an equivalent instrument in 9 target languages. Results: Analysis of 3375 pages of interview text revealed 11 underlying themes: general health perception, social relationships, emotions, energy/fatigue, sleep, cognitive functioning, physical and daily activity, coping, future, symptoms, and treatment. Seven issues new to HIV-HRQL measurement were subsumed by these themes: infection fears, future concerns, satisfaction with care, self-esteem problems, sleep problems, work disruption, and treatment issues. Of the 442 theme-related items banked, 70 items met the retention criteria and formed the pilot PROQOL-HIV instrument. Conclusions: HIV patients across 11 countries attributed a wide range of physical, mental, and social issues to their condition, many of which were not measured by existing HIV-HRQL instruments. The pilot PROQOL-HIV instrument captures these issues, is sensitive to sociocultural context, disease stage, and HAART. © 2012 Lippincott Williams &Wilkins. 2018-09-04T06:11:30Z 2018-09-04T06:11:30Z 2012-04-15 Journal 10779450 15254135 2-s2.0-84859767597 10.1097/QAI.0b013e318245cafe https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859767597&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51907 |
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Medicine Martin Duracinsky Susan Herrmann Baiba Berzins Andrew R. Armstrong Rewa Kohli Sophie Le Coeur Assane Diouf Isabelle Fournier Mauro Schechter Olivier Chassany The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
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Objectives: Health-related quality of life (HRQL) is an important outcome in HIV/AIDS infection and treatment. However, most existing HIV-HRQL instruments miss important issues (eg, sleeping problems, lipodystrophy). They were developed before highly active antiretroviral therapy (pre-HAART), and in a single language. We sought to develop a contemporary HIV-HRQL instrument (PROQOL-HIV) in multiple languages that accounts for HAART treatment and side effects. This article details the 3-stage content validation phase of PROQOL-HIV. Methods: In stage 1, we developed a conceptual model of HIVHRQL and questionnaire item bank from thematic analysis of 152 patient interviews conducted simultaneously across 9 countries. In stage 2, pilot items were selected by an expert panel to form the pilot instrument. Stage 3 involved linguistic validation and harmonization of selected items to form an equivalent instrument in 9 target languages. Results: Analysis of 3375 pages of interview text revealed 11 underlying themes: general health perception, social relationships, emotions, energy/fatigue, sleep, cognitive functioning, physical and daily activity, coping, future, symptoms, and treatment. Seven issues new to HIV-HRQL measurement were subsumed by these themes: infection fears, future concerns, satisfaction with care, self-esteem problems, sleep problems, work disruption, and treatment issues. Of the 442 theme-related items banked, 70 items met the retention criteria and formed the pilot PROQOL-HIV instrument. Conclusions: HIV patients across 11 countries attributed a wide range of physical, mental, and social issues to their condition, many of which were not measured by existing HIV-HRQL instruments. The pilot PROQOL-HIV instrument captures these issues, is sensitive to sociocultural context, disease stage, and HAART. © 2012 Lippincott Williams &Wilkins. |
format |
Journal |
author |
Martin Duracinsky Susan Herrmann Baiba Berzins Andrew R. Armstrong Rewa Kohli Sophie Le Coeur Assane Diouf Isabelle Fournier Mauro Schechter Olivier Chassany |
author_facet |
Martin Duracinsky Susan Herrmann Baiba Berzins Andrew R. Armstrong Rewa Kohli Sophie Le Coeur Assane Diouf Isabelle Fournier Mauro Schechter Olivier Chassany |
author_sort |
Martin Duracinsky |
title |
The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
title_short |
The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
title_full |
The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
title_fullStr |
The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
title_full_unstemmed |
The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS |
title_sort |
development of proqol-hiv: an international instrument to assess the health-related quality of life of persons living with hiv/aids |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859767597&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51907 |
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1681423854553006080 |