Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group

Aim: The aim of the present study was to establish Thai-specific reference ranges of triple markers for fetal Down syndrome as a function of gestational age as well as weight correction models and to compare the false positive rates when using Thai-specific model relative to Caucasian-specific model...

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Main Authors: Chanane Wanapirak, Supatra Sirichotiyakul, Suchaya Luewan, Yuri Yanase, Kuntharee Traisrisilp, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51916
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-519162018-09-04T06:11:38Z Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group Chanane Wanapirak Supatra Sirichotiyakul Suchaya Luewan Yuri Yanase Kuntharee Traisrisilp Theera Tongsong Medicine Aim: The aim of the present study was to establish Thai-specific reference ranges of triple markers for fetal Down syndrome as a function of gestational age as well as weight correction models and to compare the false positive rates when using Thai-specific model relative to Caucasian-specific model. Material and Methods: A total of 993 normal Thai pregnant women were determined for mid-trimester serum levels of alpha-fetoprotein (AFP), free-beta human chorionic gonadotropin (hCG), and unconjugated estriol (uE3), using DefiaXpress system (Perkin Elmer, Waltham, MA, USA). Results: The models of Thai-specific medians for AFP, b-hCG, and uE3, as well as the models for weight correction were derived and the normal reference ranges were constructed. The best fitted equation for AFP, b-hCG and uE3 are as follows: Predicted median = 2.675 × 10 (0.153 × GA in week), r = 0.979; 10 (-0.717 + 57.487/GA in week), r = 0.991; and 10 (5.678-69.346/GA in week), r = 0.997, respectively. The models were properly applied to another group of 302 Thai women, signifying that they were reliable models. The weight-adjusted gestation-specific medians derived from Caucasian models were significantly higher than those based on Thai models and the false positive rate could be reduced from 10 to 7.1% when Thai models were applied. Conclusion: Thai reference ranges of triple screen markers as a function of gestational age as well as weight correction models have been established. The Caucasian reference range, even after weight correction, gives a positive rate that is much higher than that it should be, strongly suggesting the need for ethnicity-specific medians. © 2012 2012 Japan Society of Obstetrics and Gynecology. 2018-09-04T06:11:38Z 2018-09-04T06:11:38Z 2012-04-01 Journal 14470756 13418076 2-s2.0-84860855459 10.1111/j.1447-0756.2011.01769.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860855459&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51916
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Chanane Wanapirak
Supatra Sirichotiyakul
Suchaya Luewan
Yuri Yanase
Kuntharee Traisrisilp
Theera Tongsong
Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
description Aim: The aim of the present study was to establish Thai-specific reference ranges of triple markers for fetal Down syndrome as a function of gestational age as well as weight correction models and to compare the false positive rates when using Thai-specific model relative to Caucasian-specific model. Material and Methods: A total of 993 normal Thai pregnant women were determined for mid-trimester serum levels of alpha-fetoprotein (AFP), free-beta human chorionic gonadotropin (hCG), and unconjugated estriol (uE3), using DefiaXpress system (Perkin Elmer, Waltham, MA, USA). Results: The models of Thai-specific medians for AFP, b-hCG, and uE3, as well as the models for weight correction were derived and the normal reference ranges were constructed. The best fitted equation for AFP, b-hCG and uE3 are as follows: Predicted median = 2.675 × 10 (0.153 × GA in week), r = 0.979; 10 (-0.717 + 57.487/GA in week), r = 0.991; and 10 (5.678-69.346/GA in week), r = 0.997, respectively. The models were properly applied to another group of 302 Thai women, signifying that they were reliable models. The weight-adjusted gestation-specific medians derived from Caucasian models were significantly higher than those based on Thai models and the false positive rate could be reduced from 10 to 7.1% when Thai models were applied. Conclusion: Thai reference ranges of triple screen markers as a function of gestational age as well as weight correction models have been established. The Caucasian reference range, even after weight correction, gives a positive rate that is much higher than that it should be, strongly suggesting the need for ethnicity-specific medians. © 2012 2012 Japan Society of Obstetrics and Gynecology.
format Journal
author Chanane Wanapirak
Supatra Sirichotiyakul
Suchaya Luewan
Yuri Yanase
Kuntharee Traisrisilp
Theera Tongsong
author_facet Chanane Wanapirak
Supatra Sirichotiyakul
Suchaya Luewan
Yuri Yanase
Kuntharee Traisrisilp
Theera Tongsong
author_sort Chanane Wanapirak
title Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
title_short Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
title_full Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
title_fullStr Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
title_full_unstemmed Different median levels of serum triple markers in the second trimester of pregnancy in a Thai ethnic group
title_sort different median levels of serum triple markers in the second trimester of pregnancy in a thai ethnic group
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860855459&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51916
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