Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified

Aims: The aim of this study was to determine the 12-week cognitive changes in topiramate-treated patients recently detoxified from alcohol. Methods: Participants were inpatients with DSM-IV alcohol dependence. All of them were discharged within 14 days after the initiation of topiramate treatment. T...

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Main Authors: Surinporn Likhitsathian, Pichai Saengcharnchai, Kanok Uttawichai, Jatsada Yingwiwattanapong, Apisak Wittayanookulluk, Manit Srisurapanont
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/51920
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spelling th-cmuir.6653943832-519202018-09-04T06:12:47Z Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified Surinporn Likhitsathian Pichai Saengcharnchai Kanok Uttawichai Jatsada Yingwiwattanapong Apisak Wittayanookulluk Manit Srisurapanont Medicine Neuroscience Aims: The aim of this study was to determine the 12-week cognitive changes in topiramate-treated patients recently detoxified from alcohol. Methods: Participants were inpatients with DSM-IV alcohol dependence. All of them were discharged within 14 days after the initiation of topiramate treatment. The topiramate dose range was 50-300 mg/day. The Montreal Cognitive Assessment (MoCA) was used on day 0, day 29, day 57, and day 85. Differences of the MoCA total and seven subtest scores among four time-points were compared. Results: Thirty-eight participants (36 men and two women) had a mean ± SD age of 43.1 ± 8.6 years old. At enrollment, they were abstinent for a mean ± SD of 11.5 ± 5.3 days. Five, one, and three patients dropped out of the study on day 29, day 57, and day 85, respectively. On day 85, the mean ± SD dose of topiramate was 253.1 ± 60.8 mg/day. Alcohol consumption decreased drastically during follow up. At each time-point, 75%-80% of the participants were continuous abstainers. The mean ± SD MoCA total, language subtest, and delayed recall subtest scores increased significantly from day 0 to day 85, from 22.0 ± 4.7 to 24.7 ± 3.4 (P < 0.01), from 1.1 ± 1.0 to 1.3 ± 1.0 (P = 0.03), and from 2.7 ± 1.7 to 4.1 ± 1.0 (P < 0.01), respectively. Conclusion: Topiramate-treated patients recently detoxified from alcohol usually have an improvement of their cognitive function, especially in the language and delayed recall domains. This phenomenon may be caused by the greater influence of cognitive recovery associated with decreased drinking as compared with topiramate-induced cognitive impairment. © 2012 Japanese Society of Psychiatry and Neurology. 2018-09-04T06:11:41Z 2018-09-04T06:11:41Z 2012-04-01 Journal 14401819 13231316 2-s2.0-84859089833 10.1111/j.1440-1819.2012.02326.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859089833&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51920
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Surinporn Likhitsathian
Pichai Saengcharnchai
Kanok Uttawichai
Jatsada Yingwiwattanapong
Apisak Wittayanookulluk
Manit Srisurapanont
Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
description Aims: The aim of this study was to determine the 12-week cognitive changes in topiramate-treated patients recently detoxified from alcohol. Methods: Participants were inpatients with DSM-IV alcohol dependence. All of them were discharged within 14 days after the initiation of topiramate treatment. The topiramate dose range was 50-300 mg/day. The Montreal Cognitive Assessment (MoCA) was used on day 0, day 29, day 57, and day 85. Differences of the MoCA total and seven subtest scores among four time-points were compared. Results: Thirty-eight participants (36 men and two women) had a mean ± SD age of 43.1 ± 8.6 years old. At enrollment, they were abstinent for a mean ± SD of 11.5 ± 5.3 days. Five, one, and three patients dropped out of the study on day 29, day 57, and day 85, respectively. On day 85, the mean ± SD dose of topiramate was 253.1 ± 60.8 mg/day. Alcohol consumption decreased drastically during follow up. At each time-point, 75%-80% of the participants were continuous abstainers. The mean ± SD MoCA total, language subtest, and delayed recall subtest scores increased significantly from day 0 to day 85, from 22.0 ± 4.7 to 24.7 ± 3.4 (P < 0.01), from 1.1 ± 1.0 to 1.3 ± 1.0 (P = 0.03), and from 2.7 ± 1.7 to 4.1 ± 1.0 (P < 0.01), respectively. Conclusion: Topiramate-treated patients recently detoxified from alcohol usually have an improvement of their cognitive function, especially in the language and delayed recall domains. This phenomenon may be caused by the greater influence of cognitive recovery associated with decreased drinking as compared with topiramate-induced cognitive impairment. © 2012 Japanese Society of Psychiatry and Neurology.
format Journal
author Surinporn Likhitsathian
Pichai Saengcharnchai
Kanok Uttawichai
Jatsada Yingwiwattanapong
Apisak Wittayanookulluk
Manit Srisurapanont
author_facet Surinporn Likhitsathian
Pichai Saengcharnchai
Kanok Uttawichai
Jatsada Yingwiwattanapong
Apisak Wittayanookulluk
Manit Srisurapanont
author_sort Surinporn Likhitsathian
title Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
title_short Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
title_full Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
title_fullStr Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
title_full_unstemmed Cognitive changes in topiramate-treated patients with alcoholism: A 12-week prospective study in patients recently detoxified
title_sort cognitive changes in topiramate-treated patients with alcoholism: a 12-week prospective study in patients recently detoxified
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859089833&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51920
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