Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women
Objective: To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. Methods...
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th-cmuir.6653943832-519542018-09-04T06:12:16Z Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women Suchaya Luewan Supatra Sirichotiyakul Yuri Yanase Kuntharee Traisrisilp Theera Tongsong Medicine Objective: To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. Methods: Serum concentrations of PAPP-A and free β-hCG were measured during the first trimester in a group of 2339 Thai women undergoing normal singleton pregnancies. Results: Thai reference ranges of PAPP-A and free β-hCG were established by gestational age (70-98 days). The equation of best fit for PAPP-A was: predicted median PAPP-A level = 28.767 - 0.781 × (gestational age in days) + 0.006 × (gestational age in days)2; r = 0.986. The equation of best fit for free β-hCG was: predicted median free β-hCG level = 465.332 × 10(-0.024 × gestational age in days); r = 0.881. Weight-corrected models were also derived for each biomarker. The Thai-specific reference ranges gave higher positive screening rates than the Caucasian-specific model, even after weight correction (5.1% versus 4.0%). The Thai-specific models were validated in an independent group of 302 pregnant women. Conclusion: Ethnic group-specific medians for PAPP-A and free β-hCG should be incorporated during first-trimester screening for fetal Down syndrome. © 2012 International Federation of Gynecology and Obstetrics. 2018-09-04T06:12:16Z 2018-09-04T06:12:16Z 2012-01-01 Journal 18793479 00207292 2-s2.0-84859575508 10.1016/j.ijgo.2011.11.026 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859575508&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51954 |
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Medicine Suchaya Luewan Supatra Sirichotiyakul Yuri Yanase Kuntharee Traisrisilp Theera Tongsong Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
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Objective: To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. Methods: Serum concentrations of PAPP-A and free β-hCG were measured during the first trimester in a group of 2339 Thai women undergoing normal singleton pregnancies. Results: Thai reference ranges of PAPP-A and free β-hCG were established by gestational age (70-98 days). The equation of best fit for PAPP-A was: predicted median PAPP-A level = 28.767 - 0.781 × (gestational age in days) + 0.006 × (gestational age in days)2; r = 0.986. The equation of best fit for free β-hCG was: predicted median free β-hCG level = 465.332 × 10(-0.024 × gestational age in days); r = 0.881. Weight-corrected models were also derived for each biomarker. The Thai-specific reference ranges gave higher positive screening rates than the Caucasian-specific model, even after weight correction (5.1% versus 4.0%). The Thai-specific models were validated in an independent group of 302 pregnant women. Conclusion: Ethnic group-specific medians for PAPP-A and free β-hCG should be incorporated during first-trimester screening for fetal Down syndrome. © 2012 International Federation of Gynecology and Obstetrics. |
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Suchaya Luewan Supatra Sirichotiyakul Yuri Yanase Kuntharee Traisrisilp Theera Tongsong |
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Suchaya Luewan Supatra Sirichotiyakul Yuri Yanase Kuntharee Traisrisilp Theera Tongsong |
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Suchaya Luewan |
title |
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
title_short |
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
title_full |
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
title_fullStr |
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
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Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women |
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median levels of serum biomarkers of fetal down syndrome detected during the first trimester among pregnant thai women |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859575508&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51954 |
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