The plausible role of antimicrobial peptides in periodontal disease

• Main Authors: Sakornrat Khongkhunthian, Vichai Reutrakul, Suttichai Krisanaprakornkit
• Format: Book
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048681793&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51963
• Institution: Chiang Mai University

© 2012 Nova Science Publishers, Inc. In this review article, a background of two families of antimicrobial peptides, including defensin and cathelicidin, and their role in periodontal disease will be discussed in detail. Members of the defensin family are cysteine-rich peptides, synthesized by plants, insects, and mammals. These peptides vary in length and in the number of disulfide bonds, and have a beta-sheet structure. In the oral cavity, four alpha-defensins are synthesized and stored in neutrophil granules, which are converted into active peptides by proteolytic processing, while three human betadefensins (hBDs), hBD-1, hBD-2, and hBD-3, are predominantly produced by oral epithelial cells. The only member of the cathelicidin family found in humans is LL-37, an alpha-helical peptide that contains 37 amino acids and begins with two leucines at its NH3-terminus. LL-37 is derived from enzymatic cleavage of a precursor peptide, namely, human cationic antimicrobial peptide 18. Clinically, differential expression of antimicrobial peptides has been reported in specific types of periodontal disease, and their presence has been shown in saliva and gingival crevicular fluid. Current evidence suggests that alpha-defensins, beta-defensins, and LL-37 have distinct, but overlapping, roles in antimicrobial and pro-inflammatory activities. Several studies have shown antimicrobial activities of hBD-2, hBD- 3, and LL-37 against several periodontal pathogens, suggesting their potential role as antimicrobial agents for periodontal disease. Although researchers initially focused their attention on antimicrobial activities, it is now becoming evident that defensins and LL-37 are multifunctional molecules that mediate various host immune responses, and may thus represent essential molecules of innate immunity in periodontal disease.