The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F....

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Main Authors: Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen Pyne, Mary Garson, Boonsom Liawruangrath
Format: Journal
Published: 2018
Subjects:
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863450704&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-519792018-09-04T06:13:22Z The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry Sorachai Khamsan Saisunee Liawruangrath Aphiwat Teerawutkulrag Stephen Pyne Mary Garson Boonsom Liawruangrath Pharmacology, Toxicology and Pharmaceutics The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on1H,13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney). 2018-09-04T06:13:22Z 2018-09-04T06:13:22Z 2012-06-01 Journal 18469558 13300075 2-s2.0-84863450704 10.2478/v10007-012-0014-1 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863450704&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Sorachai Khamsan
Saisunee Liawruangrath
Aphiwat Teerawutkulrag
Stephen Pyne
Mary Garson
Boonsom Liawruangrath
The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
description The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on1H,13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).
format Journal
author Sorachai Khamsan
Saisunee Liawruangrath
Aphiwat Teerawutkulrag
Stephen Pyne
Mary Garson
Boonsom Liawruangrath
author_facet Sorachai Khamsan
Saisunee Liawruangrath
Aphiwat Teerawutkulrag
Stephen Pyne
Mary Garson
Boonsom Liawruangrath
author_sort Sorachai Khamsan
title The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
title_short The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
title_full The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
title_fullStr The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
title_full_unstemmed The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
title_sort isolation of bioactive flavonoids from jacaranda obtusifolia h. b. k. ssp. rhombifolia (g. f. w. meijer) gentry
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863450704&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51979
_version_ 1681423867544862720

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