Neuroprotective effect against cerebral ischemia of passiflora foetida

Problem statement: Although cerebral ischemia induced by stroke has been regarded as the important problem worldwide, the therapeutic efficacy is still inadequate. Since the free radicals are implicated in the pathophysiology of cerebral ischemia, the prophylactic protection against stroke with neur...

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Main Authors: Jintanaporn Wattanathorn, Natcha Sattroopinat, Terdthai Tong-Un, Supaporn Muchmapura, Panakporn Wannanond, Panee Sirsisa-Ard
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/52031
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-520312018-09-04T06:15:59Z Neuroprotective effect against cerebral ischemia of passiflora foetida Jintanaporn Wattanathorn Natcha Sattroopinat Terdthai Tong-Un Supaporn Muchmapura Panakporn Wannanond Panee Sirsisa-Ard Multidisciplinary Problem statement: Although cerebral ischemia induced by stroke has been regarded as the important problem worldwide, the therapeutic efficacy is still inadequate. Since the free radicals are implicated in the pathophysiology of cerebral ischemia, the prophylactic protection against stroke with neuroprotective agent possessing antioxidant effect has gained much attention. Therefore, this study was designed to determine whether the alcoholic extract of Passiflora foeida, a plant possessing antioxidant activity, could protect against brain damage and impairment in the cerebral ischemia induced by the occlusion of Middle Cerebral Artery Occlusion (MCAO). Approach: Male Wistar rats, weighing 300-350 g, were orally given the extract once daily at doses of 25, 100 and 400 mg kg -1 BW at a period of 2 weeks before and 3 weeks after the occlusion of right Middle Cerebral Artery (MCAO). The animals were assessed the cerebral infarction volume at 24 h after occlusion while the neurological score and % of foot withdrawal reflex in respond to mechanical stimuli were performed after single dose and every 7 days throughout the experimental period. Results: Rats subjected to P.foetida at dose of 25 mg kg -1 BW significantly decreased brain infarct volume both in cortical and sub cortical structures. The increasing doses further to 100 and 400 mg kg -1 BW could produce the significant reduction only in cerebral cortex. In addition, it was found that the plant extract could enhance neurological score and improved sensory response to both mechanical and temperature stimuli. Conclusion: The current study clearly demonstrates the neuroprotective effect of P.foetida. Therefore P.foetida may provide the advantage as functional food to protect against cerebral ischemia induced by stroke. However, further researches about possible active ingredient and the precise underlying mechanism are still necessary. © 2012 Science Publications. 2018-09-04T06:15:59Z 2018-09-04T06:15:59Z 2012-09-13 Journal 15543641 15469239 2-s2.0-84864414594 10.3844/ajassp.2012.600.604 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864414594&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52031
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Jintanaporn Wattanathorn
Natcha Sattroopinat
Terdthai Tong-Un
Supaporn Muchmapura
Panakporn Wannanond
Panee Sirsisa-Ard
Neuroprotective effect against cerebral ischemia of passiflora foetida
description Problem statement: Although cerebral ischemia induced by stroke has been regarded as the important problem worldwide, the therapeutic efficacy is still inadequate. Since the free radicals are implicated in the pathophysiology of cerebral ischemia, the prophylactic protection against stroke with neuroprotective agent possessing antioxidant effect has gained much attention. Therefore, this study was designed to determine whether the alcoholic extract of Passiflora foeida, a plant possessing antioxidant activity, could protect against brain damage and impairment in the cerebral ischemia induced by the occlusion of Middle Cerebral Artery Occlusion (MCAO). Approach: Male Wistar rats, weighing 300-350 g, were orally given the extract once daily at doses of 25, 100 and 400 mg kg -1 BW at a period of 2 weeks before and 3 weeks after the occlusion of right Middle Cerebral Artery (MCAO). The animals were assessed the cerebral infarction volume at 24 h after occlusion while the neurological score and % of foot withdrawal reflex in respond to mechanical stimuli were performed after single dose and every 7 days throughout the experimental period. Results: Rats subjected to P.foetida at dose of 25 mg kg -1 BW significantly decreased brain infarct volume both in cortical and sub cortical structures. The increasing doses further to 100 and 400 mg kg -1 BW could produce the significant reduction only in cerebral cortex. In addition, it was found that the plant extract could enhance neurological score and improved sensory response to both mechanical and temperature stimuli. Conclusion: The current study clearly demonstrates the neuroprotective effect of P.foetida. Therefore P.foetida may provide the advantage as functional food to protect against cerebral ischemia induced by stroke. However, further researches about possible active ingredient and the precise underlying mechanism are still necessary. © 2012 Science Publications.
format Journal
author Jintanaporn Wattanathorn
Natcha Sattroopinat
Terdthai Tong-Un
Supaporn Muchmapura
Panakporn Wannanond
Panee Sirsisa-Ard
author_facet Jintanaporn Wattanathorn
Natcha Sattroopinat
Terdthai Tong-Un
Supaporn Muchmapura
Panakporn Wannanond
Panee Sirsisa-Ard
author_sort Jintanaporn Wattanathorn
title Neuroprotective effect against cerebral ischemia of passiflora foetida
title_short Neuroprotective effect against cerebral ischemia of passiflora foetida
title_full Neuroprotective effect against cerebral ischemia of passiflora foetida
title_fullStr Neuroprotective effect against cerebral ischemia of passiflora foetida
title_full_unstemmed Neuroprotective effect against cerebral ischemia of passiflora foetida
title_sort neuroprotective effect against cerebral ischemia of passiflora foetida
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864414594&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52031
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