An alternative synthesis of (+) - propranolol and (+) atenolol

An alternative synthesis of (+) - propranolol and (+) atenolol

Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai,...

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Main Authors: Rachaneebhorn Inkum, Aphiwat Teerawutgulrag, Pakawan Puangsombat, Nuansri Rakariyatham
Format: Journal
Published: 2018
Subjects:
Multidisciplinary
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867869116&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52032
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Institution: Chiang Mai University
id th-cmuir.6653943832-52032
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spelling th-cmuir.6653943832-520322018-09-04T06:16:00Z An alternative synthesis of (+) - propranolol and (+) atenolol Rachaneebhorn Inkum Aphiwat Teerawutgulrag Pakawan Puangsombat Nuansri Rakariyatham Multidisciplinary Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai, Chiang Mai, 50290 Thailand. 2018-09-04T06:16:00Z 2018-09-04T06:16:00Z 2012-09-01 Journal 19057873 2-s2.0-84867869116 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867869116&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52032
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Rachaneebhorn Inkum
Aphiwat Teerawutgulrag
Pakawan Puangsombat
Nuansri Rakariyatham
An alternative synthesis of (+) - propranolol and (+) atenolol
description Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai, Chiang Mai, 50290 Thailand.
format Journal
author Rachaneebhorn Inkum
Aphiwat Teerawutgulrag
Pakawan Puangsombat
Nuansri Rakariyatham
author_facet Rachaneebhorn Inkum
Aphiwat Teerawutgulrag
Pakawan Puangsombat
Nuansri Rakariyatham
author_sort Rachaneebhorn Inkum
title An alternative synthesis of (+) - propranolol and (+) atenolol
title_short An alternative synthesis of (+) - propranolol and (+) atenolol
title_full An alternative synthesis of (+) - propranolol and (+) atenolol
title_fullStr An alternative synthesis of (+) - propranolol and (+) atenolol
title_full_unstemmed An alternative synthesis of (+) - propranolol and (+) atenolol
title_sort alternative synthesis of (+) - propranolol and (+) atenolol
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867869116&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52032
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