An alternative synthesis of (+) - propranolol and (+) atenolol

Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai,...

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Main Authors: Rachaneebhorn Inkum, Aphiwat Teerawutgulrag, Pakawan Puangsombat, Nuansri Rakariyatham
格式: 雜誌
出版: 2018
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在線閱讀:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867869116&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52032
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