The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction

• Main Authors: Suree Lekawanvijit, Sirinart Kumfu, Bing H. Wang, Minako Manabe, Fuyuhiko Nishijima, Darren J. Kelly, Henry Krum, Andrew R. Kompa
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892549194&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52048
• Institution: Chiang Mai University

An accelerated progressive decline in renal function is a frequent accompaniment of myocardial infarction (MI). Indoxyl sulfate (IS), a uremic toxin that accumulates from the early stages of chronic kidney disease (CKD), is contributory to both renal and cardiac fibrosis. IS levels can be reduced by...