Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients
Background:The emergence and transmission of HIV-1 drug resistance (HIVDR) has raised concerns after rapid global antiretroviral therapy (ART) scale-up. There are limited data on the epidemiology of primary HIVDR in resource-limited settings in Asia. We aimed to determine the prevalence and compare...
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th-cmuir.6653943832-521032018-09-04T09:22:31Z Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients Sasisopin Kiertiburanakul Romanee Chaiwarith Sunee Sirivichayakul Rossana Ditangco Awachana Jiamsakul Patrick C.K. Li Pacharee Kantipong Christopher Lee Winai Ratanasuwan Adeeba Kamarulzaman Annette H. Sohn Somnuek Sungkanuparph Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Background:The emergence and transmission of HIV-1 drug resistance (HIVDR) has raised concerns after rapid global antiretroviral therapy (ART) scale-up. There are limited data on the epidemiology of primary HIVDR in resource-limited settings in Asia. We aimed to determine the prevalence and compare the distribution of HIVDR in a cohort of ART-naïve Asian patients with recent and chronic HIV-1 infection.Methods:Multicenter prospective study was conducted in ART-naïve patients between 2007 and 2010. Resistance-associated mutations (RAMs) were assessed using the World Health Organization 2009 list for surveillance of primary HIVDR.Results:A total of 458 patients with recent and 1,340 patients with chronic HIV-1 infection were included in the analysis. The overall prevalence of primary HIVDR was 4.6%. Recently infected patients had a higher prevalence of primary HIVDR (6.1% vs. 4.0%, p = 0.065) and frequencies of RAMs to protease inhibitors (PIs; 3.9% vs. 1.0%, p<0.001). Among those with recent infection, the most common RAMs to nucleoside reverse transcriptase inhibitors (NRTIs) were M184I/V and T215D/E/F/I/S/Y (1.1%), to non-NRTIs was Y181C (1.3%), and to PIs was M46I (1.5%). Of patients with chronic infection, T215D/E/F/I/S/Y (0.8%; NRTI), Y181C (0.5%; non-NRTI), and M46I (0.4%; PI) were the most common RAMs. K70R (p = 0.016) and M46I (p = 0.026) were found more frequently among recently infected patients. In multivariate logistic regression analysis in patients with chronic infection, heterosexual contact as a risk factor for HIV-1 infection was less likely to be associated with primary HIVDR compared to other risk categories (odds ratio 0.34, 95% confidence interval 0.20-0.59, p<0.001).Conclusions:The prevalence of primary HIVDR was higher among patients with recent than chronic HIV-1 infection in our cohort, but of borderline statistical significance. Chronically infected patients with non-heterosexual risks for HIV were more likely to have primary HIVDR. © 2013 Kiertiburanakul et al. 2018-09-04T09:20:59Z 2018-09-04T09:20:59Z 2013-06-27 Journal 19326203 2-s2.0-84879513245 10.1371/journal.pone.0062057 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879513245&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52103 |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Sasisopin Kiertiburanakul Romanee Chaiwarith Sunee Sirivichayakul Rossana Ditangco Awachana Jiamsakul Patrick C.K. Li Pacharee Kantipong Christopher Lee Winai Ratanasuwan Adeeba Kamarulzaman Annette H. Sohn Somnuek Sungkanuparph Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
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Background:The emergence and transmission of HIV-1 drug resistance (HIVDR) has raised concerns after rapid global antiretroviral therapy (ART) scale-up. There are limited data on the epidemiology of primary HIVDR in resource-limited settings in Asia. We aimed to determine the prevalence and compare the distribution of HIVDR in a cohort of ART-naïve Asian patients with recent and chronic HIV-1 infection.Methods:Multicenter prospective study was conducted in ART-naïve patients between 2007 and 2010. Resistance-associated mutations (RAMs) were assessed using the World Health Organization 2009 list for surveillance of primary HIVDR.Results:A total of 458 patients with recent and 1,340 patients with chronic HIV-1 infection were included in the analysis. The overall prevalence of primary HIVDR was 4.6%. Recently infected patients had a higher prevalence of primary HIVDR (6.1% vs. 4.0%, p = 0.065) and frequencies of RAMs to protease inhibitors (PIs; 3.9% vs. 1.0%, p<0.001). Among those with recent infection, the most common RAMs to nucleoside reverse transcriptase inhibitors (NRTIs) were M184I/V and T215D/E/F/I/S/Y (1.1%), to non-NRTIs was Y181C (1.3%), and to PIs was M46I (1.5%). Of patients with chronic infection, T215D/E/F/I/S/Y (0.8%; NRTI), Y181C (0.5%; non-NRTI), and M46I (0.4%; PI) were the most common RAMs. K70R (p = 0.016) and M46I (p = 0.026) were found more frequently among recently infected patients. In multivariate logistic regression analysis in patients with chronic infection, heterosexual contact as a risk factor for HIV-1 infection was less likely to be associated with primary HIVDR compared to other risk categories (odds ratio 0.34, 95% confidence interval 0.20-0.59, p<0.001).Conclusions:The prevalence of primary HIVDR was higher among patients with recent than chronic HIV-1 infection in our cohort, but of borderline statistical significance. Chronically infected patients with non-heterosexual risks for HIV were more likely to have primary HIVDR. © 2013 Kiertiburanakul et al. |
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Journal |
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Sasisopin Kiertiburanakul Romanee Chaiwarith Sunee Sirivichayakul Rossana Ditangco Awachana Jiamsakul Patrick C.K. Li Pacharee Kantipong Christopher Lee Winai Ratanasuwan Adeeba Kamarulzaman Annette H. Sohn Somnuek Sungkanuparph |
author_facet |
Sasisopin Kiertiburanakul Romanee Chaiwarith Sunee Sirivichayakul Rossana Ditangco Awachana Jiamsakul Patrick C.K. Li Pacharee Kantipong Christopher Lee Winai Ratanasuwan Adeeba Kamarulzaman Annette H. Sohn Somnuek Sungkanuparph |
author_sort |
Sasisopin Kiertiburanakul |
title |
Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
title_short |
Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
title_full |
Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
title_fullStr |
Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
title_full_unstemmed |
Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients |
title_sort |
comparisons of primary hiv-1 drug resistance between recent and chronic hiv-1 infection within a sub-regional cohort of asian patients |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879513245&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52103 |
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1681423890057789440 |