Improved SCFV ANTI-HIV-1 P17 binding affinity guided from the theoretical calculation of pairwise decomposition energies and Computational Alanine Scanning

• Main Authors: Panthip Tue-Ngeun, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Narin Lawan, Sawitree Nangola, Chatchai Tayapiwatana, Noorsaadah Abdul Rahman, Sharifuddin Md Zain, Vannajan Sanghiran Lee
• 格式: 雜誌
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84888588591&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52172

Computational approaches have been used to evaluate and define important residues for protein-protein interactions, especially antigen-antibody complexes. In our previous study, pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants has indicated th...