Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation

• Main Authors: Shugo Suzuki, Pornsiri Pitchakarn, Shinya Sato, Tomoyuki Shirai, Satoru Takahashi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885860674&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52198
• Institution: Chiang Mai University

Recently, considerable evidence has been generated that oxidative stress contributes to the etiology and pathogenesis of prostate cancer. The present study focused on the effects of apocynin, an inhibitor of the NADPH oxidase which generates intracellular superoxide, on a rat androgen-independent pr...