Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood

• Main Authors: Jie Zhang, Yuki Nishimoto, Harukuni Tokuda, Nobutaka Suzuki, Ken Yasukawa, Worapong Kitdamrongtham, Hiroyuki Akazawa, Aranya Manosroi, Jiradej Manosroi, Toshihiro Akihisa
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84886049602&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52208
• Institution: Chiang Mai University

The aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation induced with 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and against melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 melanoma cells, as well as potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity. Two phenolic acid derivatives, bergenin (1) and gallic acid (2), were isolated from the ethyl acetate (AcOEt)-soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV-EA activation and against skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis-inhibitory activities in α-MSH-stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical-scavenging activity. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.