Detection of β-thalassemia/hemoglobin E disease in samples which initially were diagnosed as homozygous hemoglobin E

• Main Authors: Sakorn Pornprasert, Asami Moriyama, Kanyakan Kongthai, Jarurin Waneesorn, Kanokwan Jaiping, Kallayanee Treesuwan, Yukio Hattori
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879371200&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52231
• Institution: Chiang Mai University

Background: Differentiation of β-thalassemia/HbE disease from homozygous HbE in samples containing HbA2/E > 75% and HbF < 15% is difficult. The aim of this study is to observe the possibility of using Hb typing and hematological parameters to identify both disorders. Methods: Multiplex amplifi...