Low antitubercular drug levels in newly infected normal hosts
Background: Low antitubercular drug level is a risk factor for treatment failures. Antitubercular drug level determination has been suggested for complicated tuberculosis patients, but there has been interest in performing such studies in normal hosts. Objective: To identify whether there are advant...
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| Main Authors: | , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880651160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52238 |
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| Institution: | Chiang Mai University |
| Summary: | Background: Low antitubercular drug level is a risk factor for treatment failures. Antitubercular drug level determination has been suggested for complicated tuberculosis patients, but there has been interest in performing such studies in normal hosts. Objective: To identify whether there are advantages of routine antitubercular drug level determination. Patients and Methods: We determined drug levels in 15 new normal host Thai tuberculosis patients by using published methods. All patients received the Directly Observed Treatment Short-course including pyrazinamide, rifampicin, and isoniazid. Results: We started with 15 patients of whom 27% (4 patients) were mycobacteria smear-positive, 33% (5 patients) had low blood levels of pyrazinamide and 87% had low levels of rifampicin. The drug levels in the smear-positive group were lower than in the smear-negative group. All smear-positive patients had a rifampicin levels lower than the therapeutic range. Conclusion: Antitubercular drug level determination has a potential to identify patients who may be at risk of poor treatment results. |
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