3′-R/S-Hydroxyvoacamine, a potent acetylcholinesterase inhibitor from Tabernaemontana divaricata

• Main Authors: Wantida Chaiyana, Jan Schripsema, Kornkanok Ingkaninan, Siriporn Okonogi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875950130&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52256
• Institution: Chiang Mai University

Guided by the acetylcholinesterase inhibiting activity, the bisindole alkaloid 3′-R/S-hydroxyvoacamine was isolated from a stem extract of Tabernaemontana divaricata, a plant used in Thailand in traditional rejuvenation remedies for improving the memory. The structure of the alkaloid was elucidated...