(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii

(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii

(-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone...

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Main Authors: R. Kampong, W. Pompimon, P. Meepowpan, S. Sukdee, P. Sombutsiri, N. Nantasaen, S. Krachodnok
Format: Journal
Published: 2018
Subjects:
Mathematics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887557581&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52733
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-527332018-09-04T09:31:16Z (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii R. Kampong W. Pompimon P. Meepowpan S. Sukdee P. Sombutsiri N. Nantasaen S. Krachodnok Mathematics (-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50values of 3.31, 3.26 and 1.89 μg/mL. 2018-09-04T09:31:16Z 2018-09-04T09:31:16Z 2013-11-19 Journal 0972768X 2-s2.0-84887557581 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887557581&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52733
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Mathematics
spellingShingle Mathematics
R. Kampong
W. Pompimon
P. Meepowpan
S. Sukdee
P. Sombutsiri
N. Nantasaen
S. Krachodnok
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
description (-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50values of 3.31, 3.26 and 1.89 μg/mL.
format Journal
author R. Kampong
W. Pompimon
P. Meepowpan
S. Sukdee
P. Sombutsiri
N. Nantasaen
S. Krachodnok
author_facet R. Kampong
W. Pompimon
P. Meepowpan
S. Sukdee
P. Sombutsiri
N. Nantasaen
S. Krachodnok
author_sort R. Kampong
title (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_short (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_full (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_fullStr (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_full_unstemmed (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_sort (-)-7-o-acetylgoniodiol as cancer chemopreventive agent from goniothalamus griffithii
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887557581&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52733
_version_ 1681424005069799424

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