Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand
Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpati...
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th-cmuir.6653943832-528272018-09-04T09:35:16Z Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand Thawatchai Leelahanaj Ronnachai Kongsakon Somrak Choovanichvong Sookjaroen Tangwongchai Suchat Paholpak Thoranin Kongsuk Manit Srisurapanont Medicine Neuroscience Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months. Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25-0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014). Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days. © 2013 Leelahanaj et al, publisher and licensee Dove Medical Press Ltd. 2018-09-04T09:32:59Z 2018-09-04T09:32:59Z 2013-08-21 Journal 11782021 11766328 2-s2.0-84882738527 10.2147/NDT.S47711 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882738527&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52827 |
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Medicine Neuroscience Thawatchai Leelahanaj Ronnachai Kongsakon Somrak Choovanichvong Sookjaroen Tangwongchai Suchat Paholpak Thoranin Kongsuk Manit Srisurapanont Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
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Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months. Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25-0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014). Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days. © 2013 Leelahanaj et al, publisher and licensee Dove Medical Press Ltd. |
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Journal |
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Thawatchai Leelahanaj Ronnachai Kongsakon Somrak Choovanichvong Sookjaroen Tangwongchai Suchat Paholpak Thoranin Kongsuk Manit Srisurapanont |
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Thawatchai Leelahanaj Ronnachai Kongsakon Somrak Choovanichvong Sookjaroen Tangwongchai Suchat Paholpak Thoranin Kongsuk Manit Srisurapanont |
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Thawatchai Leelahanaj |
title |
Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
title_short |
Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
title_full |
Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
title_fullStr |
Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
title_full_unstemmed |
Time to relapse and remission of bipolar disorder: Findings from a 1-year prospective study in Thailand |
title_sort |
time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in thailand |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882738527&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52827 |
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