Evaluating immunologic response and clinical deterioration in treatment-naive patients initiating first-line therapies infected with HIV-1 CRF01-AE and subtype B

• Main Authors: Rebecca A. Oyomopito, Patrick C.K. Li, Somnuek Sungkanuparph, Praphan Phanuphak, Kok Keng Tee, Thira Sirisanthana, Pacharee Kantipong, Shinichi Oka, Chris K.C. Lee, Adeeba Kamarulzaman, Jun Yong Choi, Annette H. Sohn, Matthew Law, Yi Ming A. Chen
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876374290&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52898
• Institution: Chiang Mai University

Background: HIV-1 group M viruses diverge 25%-35% in envelope, important for viral attachment during infection, and 10%-15% in the pol region, under selection pressure from common antiretrovirals. In Asia, subtypes B and CRF01-AE are common genotypes. Our objectives were to determine whether clinica...