Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease

Objective: To compare the levels of maternal serum α-fetoprotein (AFP), unconjugated estriol (uE3) and free β-human chorionic gonadotropin (free β-hCG) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. Methods: 148 pregnancies at risk of fetal Hb Bart's disease s...

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Main Authors: Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/52918
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-529182018-09-04T09:34:34Z Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Theera Tongsong Medicine Objective: To compare the levels of maternal serum α-fetoprotein (AFP), unconjugated estriol (uE3) and free β-human chorionic gonadotropin (free β-hCG) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. Methods: 148 pregnancies at risk of fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were prospectively recruited into the study. AFP, uE3 and free β-hCG concentrations were measured before cordocentesis and the final fetal diagnosis of Hb Bart's disease was based on fetal Hb typing using high-performance liquid chromatography. Results: AFP and free β-hCG were significantly higher whereas uE3 was lower in women with fetal Hb Bart's disease than those with unaffected fetuses (1.94 MoM, 1.38 MoM and 0.81 MoM respectively). Hb Bart's predictive model; probability = 1/1+e-[2.876 + 1.333(AFP) - 6.310(uE3)], effectively predicted fetal Hb Bart's disease (AUC ROC 0.91, 95% CI 0.84-0.97) with 61.5% sensitivity and 98.1% specificity using a cut-off probability at greater than 0.5. Conclusions: In triple test, serum AFP and hCG levels are significantly higher while serum uE3 is significantly lower in pregnancies with fetal Hb Bart's disease. Hb Bart's predictive model included AFP and uE3 is relatively effective and may be helpful in Hb Bart's prenatal screening. © 2013 Informa UK, Ltd. 2018-09-04T09:34:34Z 2018-09-04T09:34:34Z 2013-01-01 Journal 14764954 14767058 2-s2.0-84871392694 10.3109/14767058.2012.730583 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871392694&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52918
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
description Objective: To compare the levels of maternal serum α-fetoprotein (AFP), unconjugated estriol (uE3) and free β-human chorionic gonadotropin (free β-hCG) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. Methods: 148 pregnancies at risk of fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were prospectively recruited into the study. AFP, uE3 and free β-hCG concentrations were measured before cordocentesis and the final fetal diagnosis of Hb Bart's disease was based on fetal Hb typing using high-performance liquid chromatography. Results: AFP and free β-hCG were significantly higher whereas uE3 was lower in women with fetal Hb Bart's disease than those with unaffected fetuses (1.94 MoM, 1.38 MoM and 0.81 MoM respectively). Hb Bart's predictive model; probability = 1/1+e-[2.876 + 1.333(AFP) - 6.310(uE3)], effectively predicted fetal Hb Bart's disease (AUC ROC 0.91, 95% CI 0.84-0.97) with 61.5% sensitivity and 98.1% specificity using a cut-off probability at greater than 0.5. Conclusions: In triple test, serum AFP and hCG levels are significantly higher while serum uE3 is significantly lower in pregnancies with fetal Hb Bart's disease. Hb Bart's predictive model included AFP and uE3 is relatively effective and may be helpful in Hb Bart's prenatal screening. © 2013 Informa UK, Ltd.
format Journal
author Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
author_facet Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
author_sort Fuanglada Tongprasert
title Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
title_short Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
title_full Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
title_fullStr Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
title_full_unstemmed Second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin Bart's disease
title_sort second trimester maternal serum markers and a predictive model for predicting fetal hemoglobin bart's disease
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871392694&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52918
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