Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol

Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectro...

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Main Authors: P. Riangjanapatee, R. H. Müller, C. M. Keck, S. Okonogi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/52967
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-529672018-09-04T09:35:41Z Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi Pharmacology, Toxicology and Pharmaceutics Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature. 2018-09-04T09:35:41Z 2018-09-04T09:35:41Z 2013-09-01 Journal 00317144 2-s2.0-84884767399 10.1691/ph.2013.2139 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/52967
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
description Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature.
format Journal
author P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
author_facet P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
author_sort P. Riangjanapatee
title Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_short Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_full Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_fullStr Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_full_unstemmed Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_sort development of lycopene-loaded nanostructured lipid carriers: effect of rice oil and cholesterol
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52967
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